ICU SAQs · Pharmacology
Heparin vs warfarin — mechanism, monitoring, and the onset
A CICM First Part SAQ — UFH (antithrombin, immediate, APTT, protamine) vs warfarin (vit K antagonist, slow onset days, INR, vit K + PCC).
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Prompt
Compare the pharmacology of heparin and warfarin, including the mechanism, the onset, the monitoring, and the reversal.
Question
Compare the pharmacology of heparin and warfarin, including the mechanism, the onset, the monitoring, and the reversal.[1][2]
References3ShowHide
- [1]Garcia DA, Baglin TP, Weitz JI, Samama MM Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest, 2012.PMID 22315264
- [2]Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest, 2012.PMID 22315259
- [3]Sarode R, Milling TJ Jr, Refaai MA, et al. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study Circulation, 2013.PMID 23935011