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GP Topicspregnancy-and-reproductive-health

GP · pregnancy-and-reproductive-health

Gestational diabetes

Also known as GDM · Diabetes in pregnancy · Hyperglycaemia in pregnancy · Glucose intolerance of pregnancy

GP-fellowship guide to gestational diabetes: the continuous glucose-fetal risk link HAPO established, the ADIPS 2025 screening and diagnostic thresholds on the 75 g POGTT, the trial evidence that treating GDM reduces fetal overgrowth and shoulder dystocia (ACHOIS, Landon), lifestyle first-line therapy, metformin versus insulin (MiG, MiG TOFU), the postpartum OGTT and lifelong type 2 diabetes surveillance (Bellamy), contraception choices and breastfeeding benefit.

medium31 referencesUpdated 25 Aug 202610 min readVerification in progress

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RACGP AKTRACGP KFPRACGP CCE

Red flags

  • Fasting plasma glucose 7.0 mmol/L or more at any gestation is overt diabetes in pregnancy, not gestational diabetes — same-day endocrine and obstetric involvement changes management
  • A woman with prior GDM who misses her postpartum OGTT has a seven-fold elevated risk of type 2 diabetes going unmeasured — chase the test, do not wait for symptoms
  • Recurrent hypoglycaemia or ketones in a woman with GDM on insulin means the regimen is wrong today — review doses before the next pregnancy visit, not at it
  • Reduced fetal movements or static growth in a GDM pregnancy is an obstetric escalation, not a routine review — same-day assessment
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Target exams

RACGP AKTRACGP KFPRACGP CCE

Red flags

  • Fasting plasma glucose 7.0 mmol/L or more at any gestation is overt diabetes in pregnancy, not gestational diabetes — same-day endocrine and obstetric involvement changes management
  • A woman with prior GDM who misses her postpartum OGTT has a seven-fold elevated risk of type 2 diabetes going unmeasured — chase the test, do not wait for symptoms
  • Recurrent hypoglycaemia or ketones in a woman with GDM on insulin means the regimen is wrong today — review doses before the next pregnancy visit, not at it
  • Reduced fetal movements or static growth in a GDM pregnancy is an obstetric escalation, not a routine review — same-day assessment
Key points
  • Gestational diabetes (GDM) is hyperglycaemia first recognised in pregnancy that does not meet criteria for overt diabetes.
  • Screening in Australia is a universal 75 g two-hour oral glucose tolerance test (POGTT) at 24–28 weeks; ADIPS 2025 diagnoses GDM on fasting glucose 5.3 mmol/L or above, 1-hour 10.6 or above, or 2-hour 9.0 or above.[31]
  • Treatment halves fetal overgrowth: large-for-gestational-age birth falls from 14.5% to 7.1% and shoulder dystocia from 4.0% to 1.5% in treated mild GDM.[7]
  • Lifestyle change comes first; metformin then insulin if targets are missed. After birth: OGTT at 6–12 weeks, then lifelong type 2 diabetes surveillance, because risk runs about seven times normal.[18][5][6]

Overview

Gestational diabetes is any degree of glucose intolerance first recognised during pregnancy. It differs from overt diabetes in pregnancy, where glucose values meet diagnostic criteria for diabetes outside pregnancy. The distinction matters because overt diabetes carries higher risks and needs specialist care from diagnosis.[31]

The condition exists as a diagnosis because maternal glucose harms fetuses continuously. HAPO tested 25,505 women across nine countries with a 75 g tolerance test and blinded the results unless glucose reached diabetic levels.[4] Birth weight above the 90th percentile, cord C-peptide above the 90th percentile, caesarean delivery, neonatal hypoglycaemia and pre-eclampsia all rose linearly with fasting, 1-hour and 2-hour glucose. No threshold marked a safe zone.[4] Diagnostic cut-offs are therefore consensus lines drawn on a continuous risk curve.[8]

GDM affects roughly one in six pregnancies in Australia under modern criteria, with higher rates among Aboriginal and Torres Strait Islander peoples, South Asian, Southeast Asian and Pacific peoples, and rates rising with obesity.[29][14] Most women are diagnosed and managed in shared care with their GP, which makes the GP's test ordering, lifestyle counselling and follow-up the load-bearing steps.[14]

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References31ShowHide
  1. [1]Kim C, Newton KM, Knopp RH Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diabetes Care, 2002.PMID 12351492
  2. [2]Kahn HS, Curtis KM, Marchbanks PA Effects of injectable or implantable progestin-only contraceptives on insulin-glucose metabolism and diabetes risk. Diabetes Care, 2003.PMID 12502684
  3. [3]Crowther CA, Hiller JE, Moss JR et al. Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med, 2005.PMID 15951574
  4. [4]Metzger BE, Lowe LP, Dyer AR et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med, 2008.PMID 18463375
  5. [5]Rowan JA, Hague WM, Gao W et al. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med, 2008.PMID 18463376
  6. [6]Bellamy L, Casas JP, Hingorani AD et al. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet, 2009.PMID 19465232
  7. [7]Landon MB, Spong CY, Thom E et al. A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med, 2009.PMID 19797280
  8. [8]Metzger BE, Gabbe SG, Persson B et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care, 2010.PMID 20190296
  9. [9]Xiang AH, Kjos SL, Takayanagi M et al. Detailed physiological characterization of the development of type 2 diabetes in Hispanic women with prior gestational diabetes mellitus. Diabetes, 2010.PMID 20682697
  10. [10]Rowan JA, Rush EC, Obolonkin V et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Diabetes Care, 2011.PMID 21949222
  11. [11]Mathiesen ER, Hod M, Ivanisevic M et al. Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes. Diabetes Care, 2012.PMID 22851598
  12. [12]Chouinard-Castonguay S, Weisnagel SJ, Tchernof A et al. Relationship between lactation duration and insulin and glucose response among women with prior gestational diabetes. Eur J Endocrinol, 2013.PMID 23302255
  13. [13]VanHaltren K, Malhotra A Characteristics of infants at risk of hypoglycaemia secondary to being 'infant of a diabetic mother'. J Pediatr Endocrinol Metab, 2013.PMID 23729545
  14. [14]Nankervis A, Conn J Gestational diabetes mellitus--negotiating the confusion. Aust Fam Physician, 2013.PMID 23971059
  15. [15]Aune D, Norat T, Romundstad P et al. Breastfeeding and the maternal risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies. Nutr Metab Cardiovasc Dis, 2014.PMID 24439841
  16. [16]Middleton P, Crowther CA Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for type 2 diabetes or impaired glucose tolerance. Cochrane Database Syst Rev, 2014.PMID 24638998
  17. [17]Martis R, Brown J, Alsweiler J et al. Different intensities of glycaemic control for women with gestational diabetes mellitus. Cochrane Database Syst Rev, 2016.PMID 27055233
  18. [18]Brown J, Alwan NA, West J et al. Lifestyle interventions for the treatment of women with gestational diabetes. Cochrane Database Syst Rev, 2017.PMID 28472859
  19. [19]Brown J, Grzeskowiak L, Williamson K et al. Insulin for the treatment of women with gestational diabetes. Cochrane Database Syst Rev, 2017.PMID 29103210
  20. [20]Gunderson EP, Lewis CE, Lin Y et al. Lactation Duration and Progression to Diabetes in Women Across the Childbearing Years: The 30-Year CARDIA Study. JAMA Intern Med, 2018.PMID 29340577
  21. [21]Rowan JA, Rush EC, Plank LD et al. Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. BMJ Open Diabetes Res Care, 2018.PMID 29682291
  22. [22]Martis R, Crowther CA, Shepherd E et al. Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev, 2018.PMID 30103263
  23. [23]Davenport MH, Meah VL, Ruchat SM et al. Impact of prenatal exercise on neonatal and childhood outcomes: a systematic review and meta-analysis. Br J Sports Med, 2018.PMID 30337465
  24. [24]Guo L, Ma J, Tang J et al. Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis. J Diabetes Res, 2019.PMID 31781670
  25. [25]Behboudi-Gandevani S, Bidhendi-Yarandi R, Panahi MH et al. The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis. Front Endocrinol (Lausanne), 2021.PMID 33841332
  26. [26]Tsakiridis I, Giouleka S, Mamopoulos A et al. Diagnosis and Management of Gestational Diabetes Mellitus: An Overview of National and International Guidelines. Obstet Gynecol Surv, 2021.PMID 34192341
  27. [27]Davidson KW, Barry MJ, Mangione CM et al. Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: US Preventive Services Task Force Recommendation Statement. JAMA, 2021.PMID 34581729
  28. [28]Mimouni FB, Khoury JC, Ehrlich S et al. Embryonic, Fetal, and Neonatal Complications in Infants of Diabetic Mothers: Insights from the Cincinnati Diabetes in Pregnancy Program Project Grant. Am J Perinatol, 2025.PMID 39117332
  29. [29]McIntyre HD, Kampmann U, Dalsgaard Clausen T et al. Gestational Diabetes: An Update 60 Years After O'Sullivan and Mahan. J Clin Endocrinol Metab, 2024.PMID 39389786
  30. [30]Chen K, Tang L, Wang X et al. Prevalence and risk factors for type 2 diabetes mellitus in women with gestational diabetes mellitus: a systematic review and meta-analysis. Front Endocrinol (Lausanne), 2024.PMID 39764256
  31. [31]Sweeting A, Hare MJ, de Jersey SJ et al. Australasian Diabetes in Pregnancy Society (ADIPS) 2025 consensus recommendations for the screening, diagnosis and classification of gestational diabetes. Med J Aust, 2025.PMID 40544364

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