GP · pregnancy-and-reproductive-health
Gestational diabetes
Also known as GDM · Diabetes in pregnancy · Hyperglycaemia in pregnancy · Glucose intolerance of pregnancy
GP-fellowship guide to gestational diabetes: the continuous glucose-fetal risk link HAPO established, the ADIPS 2025 screening and diagnostic thresholds on the 75 g POGTT, the trial evidence that treating GDM reduces fetal overgrowth and shoulder dystocia (ACHOIS, Landon), lifestyle first-line therapy, metformin versus insulin (MiG, MiG TOFU), the postpartum OGTT and lifelong type 2 diabetes surveillance (Bellamy), contraception choices and breastfeeding benefit.
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Red flags
- Fasting plasma glucose 7.0 mmol/L or more at any gestation is overt diabetes in pregnancy, not gestational diabetes — same-day endocrine and obstetric involvement changes management
- A woman with prior GDM who misses her postpartum OGTT has a seven-fold elevated risk of type 2 diabetes going unmeasured — chase the test, do not wait for symptoms
- Recurrent hypoglycaemia or ketones in a woman with GDM on insulin means the regimen is wrong today — review doses before the next pregnancy visit, not at it
- Reduced fetal movements or static growth in a GDM pregnancy is an obstetric escalation, not a routine review — same-day assessment
Overview
Gestational diabetes is any degree of glucose intolerance first recognised during pregnancy. It differs from overt diabetes in pregnancy, where glucose values meet diagnostic criteria for diabetes outside pregnancy. The distinction matters because overt diabetes carries higher risks and needs specialist care from diagnosis.[31]
The condition exists as a diagnosis because maternal glucose harms fetuses continuously. HAPO tested 25,505 women across nine countries with a 75 g tolerance test and blinded the results unless glucose reached diabetic levels.[4] Birth weight above the 90th percentile, cord C-peptide above the 90th percentile, caesarean delivery, neonatal hypoglycaemia and pre-eclampsia all rose linearly with fasting, 1-hour and 2-hour glucose. No threshold marked a safe zone.[4] Diagnostic cut-offs are therefore consensus lines drawn on a continuous risk curve.[8]
GDM affects roughly one in six pregnancies in Australia under modern criteria, with higher rates among Aboriginal and Torres Strait Islander peoples, South Asian, Southeast Asian and Pacific peoples, and rates rising with obesity.[29][14] Most women are diagnosed and managed in shared care with their GP, which makes the GP's test ordering, lifestyle counselling and follow-up the load-bearing steps.[14]
References31ShowHide
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- [16]Middleton P, Crowther CA Reminder systems for women with previous gestational diabetes mellitus to increase uptake of testing for type 2 diabetes or impaired glucose tolerance. Cochrane Database Syst Rev, 2014.PMID 24638998
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- [22]Martis R, Crowther CA, Shepherd E et al. Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev, 2018.PMID 30103263
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- [25]Behboudi-Gandevani S, Bidhendi-Yarandi R, Panahi MH et al. The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis. Front Endocrinol (Lausanne), 2021.PMID 33841332
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