GP · mental-health
Anxiety disorders
Also known as Generalised anxiety disorder · Panic disorder · Social anxiety disorder · GAD
GP-fellowship guide to anxiety disorders: telling GAD, panic and social anxiety apart, GAD-7 bands with their real-world accuracy, the medical mimics to exclude, NICE stepped care from psychoeducation and digital CBT to high-intensity therapy, sertraline-first pharmacotherapy with slow onset and 12-month continuation, pregabalin as licensed adjunct, benzodiazepine limits, and measurement-based relapse prevention.
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Red flags
- New anxiety symptoms in an adult warrant exclusion of thyroid disease, arrhythmia and substance causes before a primary anxiety diagnosis is fixed
- Benzodiazepines are crisis-only in GAD and should not be prescribed for panic disorder at all — long-term use predicts worse outcomes and dependence
- SSRIs can activate: start low, go slow, warn about early jitteriness so patients do not abandon effective treatment in week one
Overview
Anxiety disorders sit at the intersection of everyday distress and diagnosable illness. A systematic review of reviews places their overall prevalence between 3.8% and 25%, with women (5.2–8.7%) and people with chronic disease carrying disproportionate burden.[16] In general practice the presentation is rarely textbook: worry, insomnia, chest discomfort and fatigue arrive together, and the anxiety label competes with thyroid disease, arrhythmia, caffeine and substance effects for explanatory space.
The course matters as much as the diagnosis. Fifteen years of NESDA cohort data show that neuroticism, low self-esteem and repetitive negative thinking predict onset, chronicity and recurrence of both depression and anxiety — transdiagnostic vulnerabilities that persist across decades. Comorbidity is the norm: GAD comorbid with depression increases hospital-admission risk (IRR 1.23) even where pure GAD alone does not.[15][17]
References20ShowHide
- [1]Bandelow B, Allgulander C, Baldwin DS et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders - Version 3. Part I: Anxiety disorders. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2023.PMID 35900161
- [2]Spitzer RL, Kroenke K, Williams JB et al. A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of internal medicine, 2006.PMID 16717171
- [3]Aktürk Z, Hapfelmeier A, Fomenko A et al. Generalized Anxiety Disorder 7-item (GAD-7) and 2-item (GAD-2) scales for detecting anxiety disorders in adults. The Cochrane database of systematic reviews, 2025.PMID 40130828
- [4]Slee A, Nazareth I, Bondaronek P et al. Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis. Lancet (London, England), 2019.PMID 30712879
- [5]Lewis G, Duffy L, Ades A et al. The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial. The lancet. Psychiatry, 2019.PMID 31543474
- [6]Cardoner N, Gutiérrez-Rojas L, Saiz P et al. Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness. Frontiers in pharmacology, 2025.PMID 39989902
- [7]Kong W, Deng H, Wan J et al. Comparative Remission Rates and Tolerability of Drugs for Generalised Anxiety Disorder: A Systematic Review and Network Meta-analysis of Double-Blind Randomized Controlled Trials. Frontiers in pharmacology, 2020.PMID 33343351
- [8]Zainal NH, Soh CP, Van Doren N et al. Do the effects of internet-delivered cognitive-behavioral therapy (i-CBT) last after a year and beyond? A meta-analysis of 154 randomized controlled trials (RCTs). Clinical psychology review, 2024.PMID 39579466
- [9]Matsumoto K, Hamatani S, Shimizu E Effectiveness of Videoconference-Delivered Cognitive Behavioral Therapy for Adults With Psychiatric Disorders: Systematic and Meta-Analytic Review. Journal of medical Internet research, 2021.PMID 34898445
- [10]Farris SG, Derby L, Kibbey MM Getting comfortable with physical discomfort: A scoping review of interoceptive exposure in physical and mental health conditions. Psychological bulletin, 2025.PMID 40014537
- [11]Kumar S, Malone D Panic disorder. BMJ clinical evidence, 2008.PMID 19445787
- [12]Lewis G, Marston L, Duffy L et al. Maintenance or Discontinuation of Antidepressants in Primary Care. The New England journal of medicine, 2021.PMID 34587384
- [13]Krijnen-de Bruin E, Scholten W, Muntingh A et al. Psychological interventions to prevent relapse in anxiety and depression: A systematic review and meta-analysis. PloS one, 2022.PMID 35960783
- [14]Remes O, Brayne C, van der Linde R et al. A systematic review of reviews on the prevalence of anxiety disorders in adult populations. Brain and behavior, 2016.PMID 27458547
- [15]Remes O, Wainwright N, Surtees P et al. Generalised anxiety disorder and hospital admissions: findings from a large, population cohort study. BMJ open, 2018.PMID 30368445
- [16]Nascimento AOD, Silva CECD, Silva MLD et al. The Effects of Caffeine on Anxiety Behavior in Healthy Individuals: A Systematic Review of the Literature. Stress and health : journal of the International Society for the Investigation of Stress, 2026.PMID 41549915
- [17]Struijs SY, de Jong PJ, Jeronimus BF et al. Psychological risk factors and the course of depression and anxiety disorders: A review of 15 years NESDA research. Journal of affective disorders, 2021.PMID 34706448
- [18]García Álvarez Á, Riera Serra P, Ricci-Cabello I et al. Effectiveness and safety of focused deprescribing interventions targeting specific drug classes in older adults across clinical settings: an umbrella systematic literature review. Age and ageing, 2026.PMID 42607278
- [19]Caldirola D, Alciati A, Daccò S et al. Relapse prevention in panic disorder with pharmacotherapy: where are we now? Expert opinion on pharmacotherapy, 2020.PMID 32543949
- [20]Bandelow B, Allgulander C, Baldwin DS, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for treatment of anxiety, obsessive-compulsive and posttraumatic stress disorders - Version 3. Part II: OCD and PTSD. The world journal of biological psychiatry, 2023.PMID 35900217