EM · Transient ischaemic attack
Transient ischaemic attack
Also known as Transient ischemic attack · TIA · Mini-stroke · Cerebral transient ischaemic attack
Transient ischaemic attack — a transient episode of focal neurological dysfunction from brain, spinal cord or retinal ischaemia WITHOUT infarction (the tissue-based definition); an infarct on diffusion-weighted MRI is a stroke, not a TIA. The ABCD2 score (Age, Blood pressure, Clinical features, Duration, Diabetes) stratifies early stroke risk; the danger is the first 48 hours. Exclude the mimics (migraine aura, postictal Todd paresis, hypoglycaemia), then urgent carotid imaging within 24 hours, aspirin 300 mg stat, short-course dual antiplatelet therapy, a high-intensity statin, and carotid endarterectomy within two weeks for symptomatic severe stenosis. A warning event, not a reassurance. ACEM-primary, globally tagged.
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- A TIA is a medical emergency, not a diagnosis to reassure and discharge — the highest stroke risk sits in the first 48 hours, and urgent assessment plus treatment cuts the 90-day stroke risk by roughly 80 per cent
- Check the finger-prick glucose first — hypoglycaemia reproduces a focal deficit with complete fidelity and is reversed in minutes if caught
- If any focal deficit is still present on assessment it is NOT a TIA — manage on the acute stroke pathway for thrombolysis, because a deficit that persists is a stroke until imaging proves otherwise
- Amaurosis fugax with a carotid bruit and atrial fibrillation points to severe symptomatic carotid stenosis — the single most impactful intervention is carotid endarterectomy within two weeks, and every hour of delay shrinks the benefit
- Never thrombolyse a deficit that has fully resolved — by definition the deficit of a TIA has gone, and alteplase has no role once the episode is over
- A patient on an anticoagulant who has a definite TIA has failed that treatment — reassess the mechanism, check adherence and the last dose, and escalate; do not simply add an antiplatelet
Meet the patient
A 72-year-old woman arrives after three episodes of left-eye visual loss in 24 hours — each a curtain descending for two to three minutes, then clearing. She has a loud left carotid bruit, hypertension, and takes aspirin 75 mg daily. The bedside glucose is normal and the deficit has fully resolved; she is alert and orientated.[1]
The two questions that decide her next hour are the two that decide every TIA: has the deficit really gone? (any persisting focal sign puts her on the stroke pathway, not the TIA pathway) and what is the mechanism — and is the carotid operable? A crescendo amaurosis fugax with a bruit points straight to severe ipsilateral internal carotid stenosis, and endarterectomy within two weeks is the single highest-impact intervention she will ever be offered. Hold those two questions and the whole topic slots into place.[7]
References9ShowHide
- [1]Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists Stroke, 2009.PMID 19423857
- [2]Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack Lancet, 2007.PMID 17258668
- [3]Rothwell PM, Giles MF, Chandratheva A, et al. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison Lancet, 2007.PMID 17928046
- [4]Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack N Engl J Med, 2013.PMID 23803136
- [5]Johnston SC, Easton JD, Farrant M, et al. Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA N Engl J Med, 2018.PMID 29766750
- [6]Amarenco P, Bogousslavsky J, Callahan A 3rd, et al. High-dose atorvastatin after stroke or transient ischemic attack N Engl J Med, 2006.PMID 16899775
- [7]Rothwell PM, Eliasziw M, Gutnikov SA, et al. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis Lancet, 2003.PMID 12531577
- [8]Barnett HJ, Taylor DW, Eliasziw M, et al. Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators N Engl J Med, 1998.PMID 9811916
- [9]European Carotid Surgery Trialists' Collaborative Group. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST) Lancet, 1998.PMID 9593407