EM · The deadly ECG patterns
The deadly ECG patterns — the emergency department recognition and immediate management
Also known as Lethal ECG patterns · STEMI equivalents · Occlusion myocardial infarction · Brugada pattern · Sodium-channel-blocker cardiotoxicity
The emergency department ECG patterns that immediately change disposition or trigger an antidote — the STEMI territories (anterior, inferior, lateral, posterior, right ventricular), the STEMI-equivalents that represent an acutely occluded artery without meeting ST-elevation thresholds (de Winter T waves, Wellens syndrome, hyperacute T waves, Sgarbossa criteria in left bundle branch block and paced rhythm), the Brugada type-1 coved pattern, the hyperkalaemia progression from peaked T to sine wave, the markedly prolonged QT and torsades de pointes, the pulmonary embolism right-heart-strain pattern, the broad-complex ventricular tachycardia, and the sodium-channel-blocker wide-QRS with an R-prime in aVR. Includes the ECG-driven drug doses — adenosine 6 mg for SVT, amiodarone 300 mg for VT, magnesium 2 g for torsades, calcium chloride 10 mL of 10% for hyperkalaemia, sodium bicarbonate for TCA toxicity. ACEM-primary, globally tagged.
Checked against its sources on 3 Sept 2026
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- The 12-lead ECG — the systematic emergency department interpretation approach
- Acute coronary syndromes (STEMI, NSTEMI and unstable angina)
- Tachyarrhythmias in the emergency department
- Bradyarrhythmias and atrioventricular block in the emergency department
- Electrolyte emergencies — potassium and sodium
- Tricyclic antidepressant poisoning (emergency department diagnosis and management)
- Pulmonary embolism (acute, in the emergency department)
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Red flags
- A regular broad-complex tachycardia is ventricular tachycardia until proven otherwise — never give verapamil, which can collapse a failing ventricle
- De Winter T waves and Wellens syndrome are anterior STEMI-equivalents from a critical proximal LAD lesion — they are treated as a STEMI activation, not observed
- Hyperkalaemia with a widened QRS or a sine wave is pre-arrest — give calcium chloride 10 mL of 10% immediately for membrane stabilisation
- A coved ST elevation of at least 2 mm in V1 to V3 followed by a negative T wave is a type-1 Brugada pattern — risk of polymorphic VT and sudden death
- In left bundle branch block or a paced rhythm, occlusion is judged by Sgarbossa criteria — concordant ST elevation, concordant ST depression in V1 to V3, or excessively discordant ST elevation
- Torsades de pointes is a polymorphic broad-complex tachycardia on a long QT — give magnesium sulphate 2 g intravenously and stop the offending drug
Meet the patient
A 68-year-old dialysis non-attender is wheeled in collapsed, his monitor showing a sine-wave bradycardia — the trace alone tells you calcium comes before the potassium result. Two cubicles away, a 58-year-old woman who is now pain-free has deeply inverted symmetrical T waves in V2–V3 on a routine ECG; sending her to the stress-test treadmill would kill her. Across the resus bay, a young man after a tricyclic overdose has a wide QRS with a prominent R-prime in aVR, and the sodium bicarbonate is already drawn up. Three traces, three antidotes, one principle: the pattern on the strip drives the first drug, and waiting for the laboratory costs the myocardium or the rhythm.[1]
References27ShowHide
- [1]de Winter RW, Adams R, Verouden NJ, et al. Precordial junctional ST-segment depression with tall symmetric T-waves signifying proximal LAD occlusion, case reports of STEMI equivalence J Electrocardiol, 2016.PMID 26560436
- [2]Maloy KR, Bhat R, Davis J, et al. Sgarbossa Criteria are Highly Specific for Acute Myocardial Infarction with Pacemakers West J Emerg Med, 2010.PMID 21079708
- [3]Quintero JA, Medina CA, Penagos F, et al. Electrocardiographic Abnormalities in Patients with Hyperkalemia: A Retrospective Study in an Emergency Department in Colombia Open Access Emerg Med, 2024.PMID 38952854
- [4]Berling I, Yates C, Hoffman RS, et al. QT interval prolongation in acute antipsychotic poisoning: systematic review and recommendations Clin Toxicol (Phila), 2025.PMID 41255343
- [5]Chua-Tuan JL, Cao D, Iwanicki JL, et al. Cardiac sodium channel blockade after an intentional ingestion of lacosamide, cyclobenzaprine, and levetiracetam: Case report Clin Toxicol (Phila), 2015.PMID 25951877
- [6]Brugada P, Brugada J, Mont L, et al. A new approach to the differential diagnosis of a regular tachycardia with a wide QRS complex Circulation, 1991.PMID 2022022
- [7]Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report J Am Coll Cardiol, 1992.PMID 1309182
- [8]de Zwaan C, Bär FWHM, Wellens HJJ. Characteristic electrocardiographic pattern indicating a critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardial infarction Am Heart J, 1982.PMID 6121481
- [9]Tzivoni D, Keren A, Cohen AM, et al. Magnesium therapy for torsades de pointes Am J Cardiol, 1984.PMID 6695782
- [10]Smith TW, Haber E, Yeatman L, Butler VP. Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies N Engl J Med, 1976.PMID 943040
- [11]Xu G, Gottschalk BH, Pérez-Riera A, et al. Link between Brugada phenocopy and myocardial ischemia: Results from the International Registry on Brugada Phenocopy Pacing Clin Electrophysiol, 2019.PMID 30924150
- [12]Geldermann N, et al. Acute hyperkalaemia in emergency care: evidence-based approaches Emerg Med J, 2026.PMID 41506858
- [13]Thomas SHL, Behr ER. Pharmacological treatment of acquired QT prolongation and torsades de pointes Br J Clin Pharmacol, 2016.PMID 26183037
- [14]Long B, Koyfman A Best Clinical Practice: Emergency Medicine Management of Stable Monomorphic Ventricular Tachycardia J Emerg Med, 2017.PMID 27751700
- [15]Littmann L, Olson EG, Gibbs MA Initial evaluation and management of wide-complex tachycardia: A simplified and practical approach Am J Emerg Med, 2019.PMID 31027937
- [16]Bruccoleri RE, Burns MM. A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening J Med Toxicol, 2016.PMID 26159649
- [17]Bradberry SM, Vale JA. Management of the cardiovascular complications of tricyclic antidepressant poisoning: role of sodium bicarbonate Toxicol Rev, 2005.PMID 16390221
- [18]Innes JA, et al. Review article: Adenosine use in the emergency department Emerg Med Australas, 2008.PMID 18549383
- [19]Schiavone M, et al. Pre-Excited Atrial Fibrillation in Wolff-Parkinson-White (WPW) Syndrome: A Case Report and a Review of the Literature Rev Cardiovasc Med, 2024.PMID 39076547
- [20]Hack JB, et al. Expert Consensus on the Diagnosis and Management of Digoxin Toxicity Am J Med, 2025.PMID 39265879
- [21]Pincus M. Management of digoxin toxicity Aust Prescr, 2016.PMID 27041802
- [22]Chan BS, Buckley NA. Digoxin-specific antibody fragments in the treatment of digoxin toxicity Clin Toxicol (Phila), 2014.PMID 25089630
- [23]Beaulieu J, et al. Antidote use for cardiac arrest or hemodynamic instability due to cardiac glycoside poisoning: A narrative review Resusc Plus, 2024.PMID 39006132
- [24]Thygesen K, Alpert JS, Jaffe AS, et al. Fourth Universal Definition of Myocardial Infarction (2018). Circulation, 2018.PMID 30571511
- [25]Smith SW, Dodd KW, Henry TD, et al. Diagnosis of ST-elevation myocardial infarction in the presence of left bundle branch block with the ST-elevation to S-wave ratio in a modified Sgarbossa rule. Ann Emerg Med, 2012.PMID 22939607
- [26]Smith SW, Khalil A, Henry TD, et al. Electrocardiographic differentiation of early repolarization from subtle anterior ST-segment elevation myocardial infarction. Ann Emerg Med, 2012.PMID 22520989
- [27]Ullman E, Brady WJ, Perron AD, et al. Electrocardiographic manifestations of pulmonary embolism. Am J Emerg Med, 2001.PMID 11593473