Derm Cases · Dermatology / Primary Care / Nail disease
OSCE — dystrophic toenails and a pigmented band: onychomycosis, psoriasis, and melanoma red flags
An 8-minute OSCE station on distinguishing onychomycosis from nail psoriasis and nail lichen planus, confirming fungus before oral antifungals, first-line terbinafine dosing, and recognising single-band melanonychia with Hutchinson's sign as subungual melanoma.
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Study tools
Target exams
NEET-PGINICETUSMLEPLABMRCP
Prompt
An 8-minute OSCE station on distinguishing onychomycosis from nail psoriasis and nail lichen planus, confirming fungus before oral antifungals, first-line terbinafine dosing, and recognising single-band melanonychia with Hutchinson's sign as subungual melanoma.
Brief (to candidate)
A 58-year-old man has yellow-brown crumbling great toenails for 2 years and asks for “the fungus tablet.” On exam you also notice a new single dark longitudinal band on the left thumbnail with pigment on the proximal nail fold. You have 8 minutes to triage nail dystrophies, confirm fungus before oral therapy, dose first-line treatment, and act on melanoma red flags.
[5]Candidate instructions
- Differentiate onychomycosis, nail psoriasis, and nail lichen planus clinically.
- State why mycologic confirmation is required before oral antifungals.
- Prescribe first-line oral terbinafine with duration and LFT monitoring.
- Recognise single-band melanonychia ± Hutchinson's sign as possible subungual melanoma.
- Name when nail matrix biopsy is mandatory.
Examiner checklist (mark each domain / 10)
| Domain | Key actions expected |
|---|---|
| Onychomycosis clues | Distal-lateral subungual yellow-brown thickening, subungual debris, onycholysis; often concurrent tinea pedis; ~50% of abnormal nails are fungal — not all dystrophy is fungus[2][4] |
| Differential | Psoriasis: pitting, oil-drop (salmon patch), onycholysis with erythematous border, often multiple nails ± skin psoriasis; lichen planus: thinning, ridging, dorsal pterygium (irreversible scarring — treat urgently)[1][3] |
| Confirm before treat | KOH, culture, or PCR before oral antifungals (hepatotoxicity, interactions, months of therapy)[2][4] |
| First-line drug | Terbinafine 250 mg daily — 6 weeks fingernails / 12 weeks toenails; baseline (± mid-course) LFTs; alternatives itraconazole pulse or fluconazole weekly when indicated[2] |
| Melanoma red flag | Single longitudinal pigmented band, new/widening, adult (esp. pale skin), Hutchinson's sign (pigment on proximal/lateral nail fold) → subungual melanoma until proven otherwise[1] |
| Biopsy pathway | Digital block; matrix-centred punch or longitudinal matrix biopsy for depth; do not rely on shave of pigment alone for staging[1] |
| Communication | Explain slow nail regrowth (months), recurrence risk, treat concurrent tinea pedis; urgent pathway for pigmented band |
Model key actions
- Confirm fungus before starting terbinafine 250 mg daily (12 weeks for toenails).[2]
- Distinguish psoriasis/LP patterns so non-fungal dystrophy is not treated as onychomycosis.[1][3]
- Escalate single-band melanonychia with Hutchinson's sign to matrix biopsy for melanoma exclusion.[1]
Common errors
- Starting oral terbinafine on clinical “fungus nails” without KOH/culture/PCR.
- Missing nail LP pterygium and delaying steroids until permanent nail loss.
- Reassuring single-band melanonychia as racial/benign without red-flag assessment.
- Shave sampling pigment without matrix depth for Breslow-capable histology.
- Forgetting LFT counselling and concurrent tinea pedis treatment.
References5ShowHide
- [1]Hwang JK, Grover C, Iorizzo M, et al. Nail psoriasis and nail lichen planus: Updates on diagnosis and management. Journal of the American Academy of Dermatology, 2024.PMID 38007038
- [2]Lipner SR, Scher RK. Onychomycosis: Treatment and prevention of recurrence. Journal of the American Academy of Dermatology, 2019.PMID 29959962
- [3]Gupta MK, Lipner SR. Review of Nail Lichen Planus: Epidemiology, Pathogenesis, Diagnosis, and Treatment. Dermatologic Clinics, 2021.PMID 33745635
- [4]Gupta AK, Stec N, Summerbell RC, et al. Onychomycosis: a review. Journal of the European Academy of Dermatology and Venereology : JEADV, 2020.PMID 32239567
- [5]Shajil C, Kumari R. Surgical Matricectomy Versus Phenolization in the Treatment of Ingrown Toenails: A Randomized Controlled Trial. Dermatologic Surgery, 2023.PMID 36735804