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Anaes VivasNeuromuscular blockade & reversal

Anaes Vivas · Neuromuscular blockade & reversal

Suxamethonium: depolarising block and its problems

Viva on the pharmacology of suxamethonium, the phase I/II block, and its safety profile.

data3 min readVerification in progress

Target exams

ANZCAFRCAABAEDAICFCAIFCA_SA
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Target exams

ANZCAFRCAABAEDAICFCAIFCA_SA
Prompt
A train-of-four trace showing a phase I depolarising block (four equal but reduced twitches, no fade) beside a phase II block trace (clear fade, T4 smaller than T1).

Stimulus

A train-of-four trace showing a phase I depolarising block (four equal but reduced twitches, no fade) beside a phase II block trace (clear fade, T4 smaller than T1).

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References4ShowHide
  1. [1]Martyn JA, Richtsfeld M Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology, 2006.PMID 16394702
  2. [2]O'Connell DH, et al. Outcomes of Succinylcholine and Rocuronium for Rapid Sequence Intubation in the Emergency Department. West J Emerg Med, 2026.PMID 42258841
  3. [5]Fang Y, Mei W, Bi J Considerations for diverse RYR1 variants in malignant hyperthermia susceptible patients: a report of two cases. BMC Anesthesiol, 2026.PMID 42271251
  4. [7]Puxty KA, et al. Cardiac arrest in adult patients following burn injury: a scoping review with expert recommendations on management. Scand J Trauma Resusc Emerg Med, 2026.PMID 41507944
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