Anaes Vivas · Airway management
Data viva — the classical versus the modified rapid sequence induction
A data viva comparing the classical and the modified rapid sequence induction side by side. Covers the seven classical steps and their rationale, the five modern modifications and the evidence behind each (gentle ventilation to prevent hypoxaemia, THRIVE extending safe apnoea through the continuous apnoeic oxygenation gradient, rocuronium-sugammadex removing the CICO objection), the cricoid pressure controversy that bridges the two, and the induction agent and paralytic choice governed by haemodynamic reserve.
On this page
Study tools
Target exams
Stimulus
A two-column timeline comparing the two techniques. The left column shows the seven-step classical RSI as numbered panels: 1 Preoxygenation (100 per cent oxygen for three minutes or eight vital-capacity breaths), 2 Pre-treatment (optional opioid), 3 Induction (thiopental or propofol or ketamine), 4 Paralysis (suxamethonium 1 to 1.5 mg per kg or rocuronium 1.2 mg per kg), 5 No mask ventilation with cricoid pressure applied before loss of consciousness, 6 Intubation at 45 to 60 seconds, 7 Confirmation by waveform capnography then release of cricoid pressure. The right column overlays the five modifications that define the modern RSI: gentle mask ventilation during the apnoeic period, reduced or omitted cricoid pressure, THRIVE high-flow nasal apnoeic oxygenation at 70 L per min, video laryngoscopy as first-line, and rocuronium 1.2 mg per kg with sugammadex 16 mg per kg rescue. A vertical arrow marks the 45 to 60 second onset window shared by both sequences.
[1]References14ShowHide
- [1]Caputo ND, et al. End Tidal O2: A Promising New Metric for Optimizing Preoxygenation and RSI Safety. Acad Emerg Med, 2026.PMID 42340046
- [2]Kumar J, et al. Cervical Spine Movements With Single-Handed Versus Bimanual Cricoid Pressure. J Neurosurg Anesthesiol, 2026.PMID 42333579
- [3]O'Connell DH, et al. Outcomes of Succinylcholine and Rocuronium for Rapid Sequence Intubation. West J Emerg Med, 2026.PMID 42258841
- [4]Freund Y, et al. Improving the safety of emergency tracheal intubation. Curr Opin Crit Care, 2026.PMID 42170830
- [5]Sheridan B, et al. Maintenance of prehospital anaesthesia using an intermittent bolus regime. Scand J Trauma Resusc Emerg Med, 2026.PMID 42351216
- [6]Ghaffar S, et al. Physiological difficult airway management in the emergency department. JPMA, 2026.PMID 42363338
- [7]Russotto V, et al. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries (INTUBE). JAMA, 2021.PMID 33755076
- [8]Nimmagadda U, et al. Preoxygenation: Physiologic Basis, Benefits, and Potential Risks. Anesth Analg, 2017.PMID 28099321
- [9]Patel A, et al. Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE). Anaesthesia, 2015.PMID 25388828
- [10]Lee C, et al. Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium. Anesthesiology, 2009.PMID 19387176
- [11]Meek T, et al. Cricoid pressure: can protective force be sustained? Br J Anaesth, 1998.PMID 9691875
- [12]Yentis SM Suxamethonium and hyperkalaemia. Anaesth Intensive Care, 1990.PMID 2186663
- [13]Mendelson CL The aspiration of stomach contents into the lungs during obstetric anesthesia. Am J Obstet Gynecol, 1946.PMID 20993766
- [14]Mushambi MC, Kinsella SM, Popat M, et al. Obstetric Anaesthetists' Association and Difficult Airway Society guidelines for the management of difficult and failed tracheal intubation in obstetrics. Anaesthesia, 2015.PMID 26449292