Anaes Vivas · Applied cardiovascular & respiratory physiology
Data viva — the three-compartment model
A Primary data viva — read the compartment model; define Vd, CL and t1/2; explain CSHT and redistribution.
On this page
Study tools
Target exams
ANZCAFRCAABAEDAIC
Prompt
A Primary data viva — read the compartment model; define Vd, CL and t1/2; explain CSHT and redistribution.
Stimulus
A three-compartment model diagram shows V1 (central), V2 (muscle) and V3 (fat) with intercompartmental flows and clearance. Define Vd and CL, state the half-life equation, and explain why the CSHT increases with infusion duration.
References1ShowHide
- [1]Hughes MA, Glass PSA, Jacobs JR. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology, 1992.PMID 1539843