Anaes Vivas · Measurement & monitoring physics
Data viva — the oxyhaemoglobin dissociation curve
A data viva on the oxyhaemoglobin dissociation curve — the sigmoid shape, the flat top that makes SpO2 a late index of PaO2, the P50 at 3.5 kPa (26.8 mmHg), the left-shift factors (alkalosis, hypothermia, low 2,3-DPG) and the right-shift factors (acidosis, hyperthermia, high 2,3-DPG), and how the pulse oximeter's two wavelengths map onto it.
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Target exams
Stimulus
You are shown the oxyhaemoglobin dissociation curve, with saturation on the y-axis against PaO2 in kPa on the x-axis. The curve is sigmoid. A dashed line marks the P50 at 3.5 kPa. Two further curves show a left shift (labelled alkalosis, hypothermia, low 2,3-DPG) and a right shift (labelled acidosis, hyperthermia, high 2,3-DPG). An inset shows the two wavelengths of the pulse oximeter at 660 nm and 940 nm. Interpret the graph.
References3ShowHide
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- [3]Atuar B, et al. Reduce hypoxemia overestimation in pulse oximetry based on iso-pathlength: a Monte Carlo study. Opt Lett, 2026.PMID 42066129
- [7]Shi Y, et al. Diffusion correction of Beer-Lambert law in visible light optical coherence tomography for retinal vessels. Med Biol Eng Comput, 2026.PMID 42008039