Anaes Vivas · Opioids & analgesics
Data viva — the context-sensitive half-time
A data viva on the CSHT — the remifentanil flat (3 5 min regardless); the fentanyl rises steeply; the sufentanil less steep; the morphine long. The clinical implications.
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ANZCAFRCAABAEDAIC
Prompt
A graph of the context-sensitive half-time vs the infusion duration for the fentanyl, the remifentanil, the sufentanil, and the morphine. Interpret and advise.
Stimulus
A graph shows the context-sensitive half-time (CSHT) against the infusion duration for the fentanyl, the remifentanil, the sufentanil, and the morphine — confirm exact curve values against local pharmacology teaching; the held model defines CSHT as the time for plasma concentration to fall by 50% after stopping an infusion of a given duration.[1]
References2ShowHide
- [1]Hughes MA, et al. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology, 1992.PMID 1539843
- [2]Davis PJ, et al. The use of ultra-short-acting opioids in paediatric anaesthesia: the role of remifentanil. Clin Pharmacokinet, 2005.PMID 16029065