Anaes Vivas · Local anaesthetic pharmacology
Local anaesthetic dosing and toxicity
Viva on local-anaesthetic maximum doses, determinants of onset/duration, and LAST management.
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Prompt
A table of the local anaesthetics with their maximum dose plain and with adrenaline (mg per kg), and a graph of plasma concentration versus time for intercostal versus subcutaneous injection.
Stimulus
You are shown a table of the common local anaesthetics with their maximum recommended dose, plain and with adrenaline, expressed in mg per kg. Alongside it is a graph plotting plasma concentration against time after injection of the same mg per kg dose at two sites: an intercostal space and a subcutaneous infiltration site.
References2ShowHide
- [1]Christensen SA, Shipp EM. MaxSafe: a mobile-friendly calculator for fractional local anesthetic toxicity and epinephrine dose tracking in dental practice. J Dent Anesth Pain Med, 2026.PMID 42266421
- [2]Meral RM, Nagpal AS, Wasserman R. International Pain and Spine Intervention Society Emergency Protocols: Local Anesthetic Systemic Toxicity (LAST). Interv Pain Med, 2026.PMID 42325878