Anaes Vivas · Applied cardiovascular & respiratory physiology
Data viva — hepatic drug metabolism
A Primary data viva — read the metabolism flowchart; contrast Phase I and II; define extraction ratio; predict the effect of an inhibitor such as itraconazole.
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Prompt
A Primary data viva — read the metabolism flowchart; contrast Phase I and II; define extraction ratio; predict the effect of an inhibitor such as itraconazole.
Stimulus
A horizontal flowchart shows drug metabolism through Phase I (CYP450), Phase II (conjugation) and excretion. Outline each phase, state the difference between high- and low-extraction drugs, and predict the effect of CYP inhibition.[1]
References2ShowHide
- [1]Scudamore O, et al. The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers. Pharmacotherapy, 2026.PMID 42324472
- [5]Monet C, et al. Impact of Molecular Adsorbent Recirculating System Therapy on Piperacillin Concentration in Critically Ill Patients: An Observational Cohort Study. Crit Care Med, 2026.PMID 42301229