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Anaes VivasAnaesthetic adjuncts

Anaes Vivas · Anaesthetic adjuncts

Fentanyl versus remifentanil versus morphine

Viva comparing fentanyl, remifentanil and morphine pharmacology.

data3 min readVerification in progress

Target exams

ANZCAFRCAABAEDAICFCAIFCA_SA
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Target exams

ANZCAFRCAABAEDAICFCAIFCA_SA
Prompt
A context-sensitive half-time graph showing remifentanil (flat), fentanyl (rising) and a comparison table of fentanyl and morphine.

Stimulus

A context-sensitive half-time graph showing remifentanil (flat), fentanyl (rising) and a comparison table of fentanyl and morphine.

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References8ShowHide
  1. [1]Ramos-Matos CF, et al. Fentanyl StatPearls, 2023.PMID 29083586
  2. [3]Bowdle TA Adverse effects of opioid agonists and agonist-antagonists in anaesthesia Drug Saf, 1998.PMID 9747665
  3. [4]Baldo BA, et al. Opioid toxicity: histamine, hypersensitivity, and MRGPRX2 Arch Toxicol, 2023.PMID 36344690
  4. [5]Feierman DE, et al. Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4 Drug Metab Dispos, 1996.PMID 8886601
  5. [6]Hughes MA, et al. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs Anesthesiology, 1992.PMID 1539843
  6. [7]Egan TD Remifentanil pharmacokinetics and pharmacodynamics. A preliminary appraisal Clin Pharmacokinet, 1995.PMID 7586903
  7. [8]Lewis T, et al. Acute fentanyl toxicity: from opioid-induced to hypoxia-mediated pathophysiology J Neurophysiol, 2026.PMID 42333655
  8. [10]Voronkov M, et al. Does Kappa Agonism Improve Reversal of 'Tranq-Dope' Overdose? Evidence from a Rodent Model Pharmaceuticals (Basel), 2026.PMID 42356464
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