Anaes Vivas · Applied cardiovascular & respiratory physiology
Data viva — the CO2 dissociation curve
A Primary data viva — read the CO2 curve; explain why deoxy blood carries more CO2 (Haldane); contrast the near-linear CO2 curve with the sigmoid O2 curve; explain the venous-to-arterial CO2 gap as a perfusion marker.
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Prompt
Two CO2 dissociation curves are shown: deoxygenated blood (upper) and oxygenated blood (lower), with the Haldane effect marked between them. Explain the Haldane effect, the shape of the curve, and the clinical use of the venous-to-arterial CO2 difference.
Stimulus
Two CO2 dissociation curves are shown: deoxygenated blood (upper) and oxygenated blood (lower), with the Haldane effect marked between them. Explain the Haldane effect, the shape of the curve, and the clinical use of the venous-to-arterial CO2 difference.
References2ShowHide
- [1]O'Neill DP, Robbins PA. A mechanistic physicochemical model of carbon dioxide transport in blood. J Appl Physiol, 2017.PMID 27881667
- [3]Ospina-Tascon GA, et al. Regional venous-to-arterial carbon dioxide pressure and content differences during endotoxemic shock: influence of hydrogen ion accumulation vs. Haldane effect. Intensive Care Med Exp, 2025.PMID 40921906