Anaes Vivas · Anaphylaxis under anaesthesia
Data viva — the serum tryptase result
A data viva on the interpretation of serial serum tryptase — the peak-to-baseline rise confirms mast-cell degranulation, the threshold for significance, and what a normal tryptase does and does not mean.
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ANZCAFRCAABAEDAIC
Prompt
A laboratory report showing a serum tryptase of 45 micrograms per litre at 1 hour (peak) and 6 micrograms per litre at baseline (24 hours). Normal is less than 11.4.
Stimulus
A laboratory report on a patient who had a perioperative cardiovascular collapse. The serum tryptase is 45 micrograms per litre at 1 hour (the peak sample), and 6 micrograms per litre at baseline (24 hours). The laboratory normal range is up to 11.4 micrograms per litre. Interpret the result.
References2ShowHide
- [4]Littlejohns A, Savic S, Hopkins PM, et al. Diagnostic certainty after investigation of perioperative hypersensitivity. British Journal of Anaesthesia, 2026.PMID 41680037
- [5]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.