Anaes SAQs · Volatile & inhalational agents
The pharmacokinetics of the inhaled anaesthetics — uptake and solubility
The Primary (basic-science) volatile PK question: alveolar partial pressure and FA/FI, the determinants of uptake, the blood:gas coefficient, and the concentration and second-gas effects.
On this page
Study tools
Target exams
ANZCAFRCAABAEDAIC
Prompt
Outline the pharmacokinetics of the inhaled anaesthetic agents. Explain how the blood:gas partition coefficient determines the rate of induction and emergence, and describe the concentration and second-gas effects.
Question
Outline the pharmacokinetics of the inhaled anaesthetic agents. Explain how the blood:gas partition coefficient determines the rate of induction and emergence, and describe the concentration and second-gas effects.
References6ShowHide
- [9]Eger EI 2nd Desflurane animal and human pharmacology: aspects of kinetics, safety, and MAC. Anesthesia and analgesia, 1992.PMID 1524237
- [10]Esper T, Wehner M, Meinecke CD, et al. Blood/Gas partition coefficients for isoflurane, sevoflurane, and desflurane in a clinically relevant patient population. Anesthesia and analgesia, 2015.PMID 25393590
- [11]Taheri S, Eger EI 2nd A demonstration of the concentration and second gas effects in humans anesthetized with nitrous oxide and desflurane. Anesthesia and analgesia, 1999.PMID 10475324
- [12]Korman B, Mapleson WW Concentration and second gas effects: can the accepted explanation be improved? British journal of anaesthesia, 1997.PMID 9175984
- [14]Shandong New Time Pharmaceutical Co., Ltd. SEVOFLURANE liquid — prescribing information. DailyMed, 2026.Source
- [18]Dale O, Brown BR Jr Clinical pharmacokinetics of the inhalational anaesthetics. Clinical pharmacokinetics, 1987.PMID 3555939