Anaes SAQs · Trauma & massive haemorrhage
The massive transfusion protocol and the tranexamic acid
Primary — the MTP (the protocolised delivery, the activation, the products); the 1-to-1-to-1 ratio (the PROPPR trial); the tranexamic acid (the CRASH-2, the early-within-3-hours, the 1 g + 1 g); the calcium replacement.
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Prompt
Describe the massive transfusion protocol, the 1-to-1-to-1 ratio, and the role of the tranexamic acid.
Question
Describe the massive transfusion protocol, the 1-to-1-to-1 ratio, and the role of the tranexamic acid.
References3ShowHide
- [3]Mitchell AM, et al. Management of trauma-induced coagulopathy in the perioperative setting. Transfusion, 2026.PMID 42233229
- [4]Winearls J, et al. Clinical outcomes of hemostatic interventions in patients with traumatic injury. J Trauma Acute Care Surg, 2026.PMID 42296330
- [42296331]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.