Anaes SAQs · TIVA & target-controlled infusion
Effect-site targeting in clinical TIVA practice
Final-viva question on the clinical practice of effect-site TIVA: the plasma-to-effect-site hysteresis and ke0, induction and maintenance, the propofol-remifentanil combination, titration to a processed-EEG depth monitor, and the use of TIVA for shared-airway surgery.
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Prompt
Describe how you would induce and maintain anaesthesia using propofol-remifentanil target-controlled infusion with effect-site targeting for a fit adult undergoing microlaryngoscopy. Explain how effect-site targeting differs from plasma targeting and how you would monitor depth.
Question
Describe how you would induce and maintain anaesthesia using propofol-remifentanil target-controlled infusion with effect-site targeting for a fit adult undergoing microlaryngoscopy. Explain how effect-site targeting differs from plasma targeting and how you would monitor depth[3][1].
References4ShowHide
- [1]He ZY, et al. Comparison of propofol-remifentanil target-controlled infusion with lidocaine versus neuromuscular blockade for laryngoscopy. Minerva Anestesiol, 2026.PMID 42267885
- [2]Stretch B, et al. Peri-operative care of patients undergoing robotic-assisted bronchoscopy under general anaesthesia - a single-centre retrospective cohort study. Anaesth Rep, 2026.PMID 42283065
- [3]Sahinovic MM, Struys MMRF, et al. Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clin Pharmacokinet, 2018.PMID 30019172
- [4]Newman D, et al. Reframing "paradoxical" excitation: disentangling electroencephalogram complexity and entropy reveals resting-state dynamics associated with propofol susceptibility in healthy adults. Br J Anaesth, 2026.PMID 42225443