Anaes SAQs · Anaesthetic adjuncts
Remifentanil pharmacology
Short-answer question on remifentanil pharmacokinetics, the flat context-sensitive half-time, and acute tolerance/hyperalgesia.
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Prompt
Describe the pharmacokinetics of remifentanil, explain the concept of context-sensitive half-time, and outline the clinical importance of acute tolerance and opioid-induced hyperalgesia.
Question
Describe the pharmacokinetics of remifentanil, explain the concept of context-sensitive half-time, and outline the clinical importance of acute tolerance and opioid-induced hyperalgesia.
References2ShowHide
- [1]Kazokas D, et al. The Effects of Low-Dose Remimazolam Adjunct on Propofol-Remifentanil Anaesthesia in Day Case Gynaecological Surgery: A Retrospective Cohort Study. Medicina (Kaunas), 2026.PMID 42356189
- [2]Wang YM, et al. Feasibility and safety of an analgesia-first strategy without hypnotic sedatives in adult patients admitted to the intensive care unit after neurosurgical craniotomy: a protocol for a single-arm, single-center exploratory prospective study. Front Med (Lausanne), 2026.PMID 42359072