Anaes SAQs · Applied cardiovascular & respiratory physiology
Pharmacokinetics: compartment models
Primary — three-compartment model (V1 central, V2 muscle, V3 fat); Vd (apparent volume, large for lipophilic); CL (maintenance rate equals Cp x CL); t1/2 equals 0.693 Vd over CL; CSHT increases with infusion duration for lipophilic drugs; redistribution mechanism of IV bolus recovery; TCI models (Marsh, Schnider, Eleveld, Minto); remifentanil ester metabolism constant CSHT.
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Prompt
Describe the three-compartment pharmacokinetic model. Define volume of distribution, clearance and half-life, and explain the concept of context-sensitive half-time and the mechanism of redistribution.
Question
Describe the three-compartment pharmacokinetic model. Define volume of distribution, clearance and half-life, and explain the concept of context-sensitive half-time and the mechanism of redistribution.
References4ShowHide
- [1]Ye J, et al. A Prospective Study of Marsh PK-PD Model and Schnider PK-PD Model During Anesthesia Induction for Obese Patients Undergoing Elective Heart Surgery. Pharmacol Res Perspect, 2026.PMID 42286797
- [4]Dong Y. Remimazolam in anesthesia and sedation: A narrative review. J Anesth Transl Med, 2025.PMID 41929379
- [6]Marques L, et al. Model-Based Virtual Clinical Trial Reveals Renal Impairment and Body Size as Key Determinants of Pharmacokinetic Variability and Drug-Drug Interaction Risk in Propranolol Therapy. Pharmaceutics, 2026.PMID 42357253
- [2]Introna M, et al. Target concentrations of propofol predicted by four different pharmacokinetic/pharmacodynamic models to induce loss of consciousness in neurosurgical patients. J Anesth Analg Crit Care, 2026.PMID 42231496