Anaes SAQs · Paediatric anaesthesia
Anaesthesia-induced developmental neurotoxicity and the GAS trial
The developmental neurotox SAQ — the animal data (neuronal apoptosis), the human cohort studies (inconclusive), and the GAS trial (the definitive RCT: no difference at 5 years for a single brief exposure).
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Prompt
Outline the concern about anaesthesia-induced developmental neurotoxicity, the evidence from animal and human studies, and what the GAS trial concluded.
Question
Outline the concern about anaesthesia-induced developmental neurotoxicity, the evidence from animal and human studies, and what the GAS trial concluded.
[2]References2ShowHide
- [1]McCann ME, et al. Differences in Blood Pressure in Infants After General Anesthesia Compared to Awake Regional Anesthesia (GAS Study-A Prospective Randomized Trial). Anesthesia & Analgesia, 2017.PMID 28489641
- [2]Vutskits L, Davidson A. Clinical investigations on anesthesia-induced developmental neurotoxicity: The knowns, the unknowns and future prospects. Best Pract Res Clin Anaesthesiol, 2023.PMID 37295853