Anaes SAQs · Applied cardiovascular & respiratory physiology
The oxyhaemoglobin dissociation curve
Primary — oxygen content equation; sigmoid curve, plateau vs steep portion; P50 26.8 mmHg as affinity index; right shift (H+, CO2, temp, 2,3-DPG) Bohr; left shift (mirror, preterm neonates); CO2 transport 90/5/5; Haldane; DO2 as cardiac output times content.
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Prompt
Describe the oxyhaemoglobin dissociation curve. Define P50 and explain the factors that shift the curve, and their effect on oxygen loading and unloading.
Question
Describe the oxyhaemoglobin dissociation curve. Define P50 and explain the factors that shift the curve, and their effect on oxygen loading and unloading.[1]
References4ShowHide
- [1]Dash RK, Korman B, et al. Simple accurate mathematical models of blood HbO2 and HbCO2 dissociation curves at varied physiological conditions: evaluation and comparison with other models. Eur J Appl Physiol, 2016.PMID 26298270
- [2]Demir ZA, Bingül ES, et al. Foundations and Advancements in Hemodynamic Monitoring: Part I-Elements of Hemodynamics. Turk J Anaesthesiol Reanim, 2025.PMID 40150830
- [3]Mallat J, Jozwiak M, et al. Use of CO(2)-derived variables in critically ill patients. Ann Intensive Care, 2025.PMID 40999252
- [4]Karakurt Y, Can E. Association of Day-1 Hemoglobin Oxygen Affinity (p50) with Severe Intraventricular Hemorrhage in Preterm Infants. Indian Pediatr, 2026.PMID 41949748