Anaes SAQs · Volatile & inhalational agents
Nitrous oxide and closed gas spaces
Short-answer question on the mechanism of closed-gas-space expansion by nitrous oxide and its other key adverse effects.
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Prompt
Explain why nitrous oxide is contraindicated in the patient with a pneumothorax, and outline the other clinically important adverse effects of nitrous oxide.
Question
Explain why nitrous oxide is contraindicated in the patient with a pneumothorax, and outline the other clinically important adverse effects of nitrous oxide.
References3ShowHide
- [4]Almujaiwel N, et al. Effect of Anesthetic Agents on Middle Ear Pressure: Systematic Review and Meta-Analysis. Saudi Med J, 2026.PMID 42293722
- [1]Li W, et al. A case report of nitrous oxide-induced subacute combined degeneration complicated with neurosyphilis in a 23-year-old female BMC Neurol, 2026.PMID 42321648
- [5]Korman B, et al. Effects of N(2)O elimination on the elimination of second gases in a two-step mathematical model of heterogeneous gas exchange Physiol Rep, 2023.PMID 37923389