Anaes SAQs · Neuromuscular blockade & reversal
Neostigmine reversal of neuromuscular blockade
Short-answer question on neostigmine reversal: mechanism, dose, muscarinic effects and the need for glycopyrrolate.
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Prompt
Outline the mechanism, dosing and adverse effects of neostigmine for reversal of a non-depolarising neuromuscular block, and explain why an anticholinergic must be co-administered.
Question
Outline the mechanism, dosing and adverse effects of neostigmine for reversal of a non-depolarising neuromuscular block, and explain why an anticholinergic must be co-administered.
[3]References3ShowHide
- [6]Krönauer T, Girrbach F, Simon P, Heller AR. [Muscle relaxation and neuromuscular monitoring : Current findings and recommendations for the clinical practice]. Anaesthesiologie, 2026.PMID 42334564
- [5]Tao JC, Zhou XY, Wang TT, et al. Current status of neuromuscular reversal and neuromuscular monitoring in China: a cross-sectional survey. BMC Anesthesiol, 2026.PMID 42185770
- [3]Leslie K, Darvall JN, Chan MTV, et al. Sugammadex versus neostigmine for reversal of neuromuscular blockade and postoperative pulmonary complications (SNaPP): an international, randomised, controlled, phase 4 trial. Lancet Respir Med, 2026.PMID 42263720