Anaes SAQs · Anaesthetic adjuncts
Pharmacology and adverse effects of morphine
Short-answer question on morphine pharmacology, adverse effects and the renal-failure caution.
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Prompt
Outline the mechanism of action, pharmacokinetics and principal adverse effects of morphine, and explain why caution is needed in renal failure.
Question
Outline the mechanism of action, pharmacokinetics and principal adverse effects of morphine, and explain why caution is needed in renal failure.
References5ShowHide
- [1]Hermens JM, Ebertz JM, Hanifin JM, et al. Comparison of histamine release in human skin mast cells induced by morphine, fentanyl, and oxymorphone. Anesthesiology, 1985.PMID 2578752
- [2]Klimas R, Mikus G, et al. Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration. Br J Anaesth, 2014.PMID 24985077
- [3]Slater NA, Todd AM, Trimmier MC, et al. Morphine Use in Renal Failure: A Case Report of Single-Dose Morphine Toxicity in a Patient Requiring Peritoneal Dialysis. J Pharm Pract, 2020.PMID 31248317
- [4]Dahan A, Aarts L, et al. Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression. Anesthesiology, 2010.PMID 20010421
- [7]Edinoff AN, Kaplan LA, et al. Full Opioid Agonists and Tramadol: Pharmacological and Clinical Considerations. Anesthesiol Pain Med, 2021.PMID 34692448