Anaes SAQs · Malignant hyperthermia
The pathophysiology of malignant hyperthermia
The Primary (basic-science) MH question — excitation-contraction coupling, the RYR1 channel on the sarcoplasmic reticulum, the uncontrolled calcium release, and the downstream hypermetabolism (ATP consumption, heat, carbon dioxide, rhabdomyolysis, hyperkalaemia). Anchored to the McCarthy RYR1 review.
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Prompt
Outline the cellular pathophysiology of malignant hyperthermia. Include the role of the ryanodine receptor, the consequence for intracellular calcium, and how these produce the clinical hypermetabolic state.
Question
Outline the cellular pathophysiology of malignant hyperthermia. Include the role of the ryanodine receptor, the consequence for intracellular calcium, and how these produce the clinical hypermetabolic state.
References3ShowHide
- [14]McCarthy TV, Quane KA, Lynch PJ. Ryanodine receptor mutations in malignant hyperthermia and central core disease. Human Mutation, 2000.PMID 10790202
- [1]Rosenberg H, Pollock N, Schiemann A, Bulger T, Stowell K. Malignant hyperthermia: a review. Orphanet Journal of Rare Diseases, 2015.PMID 26238698
- [15]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.