Anaes SAQs · Intravenous induction agents
Etomidate and the adrenal cortex — the sepsis controversy
The etomidate-adrenal SAQ — the 11-beta-hydroxylase inhibition, even from a single dose, the Albert 2011 meta-analysis confirming adrenal insufficiency, the unresolved mortality question, and the ketamine alternative.
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Prompt
Discuss the effect of etomidate on the adrenal cortex, the evidence for and against increased mortality in the critically ill, and how this influences your choice of induction agent in septic shock.
Question
Discuss the effect of etomidate on the adrenal cortex, the evidence for and against increased mortality in the critically ill, and how this influences your choice of induction agent in septic shock.
[1]References1ShowHide
- [1]Albert SG, Ariyan S, Rather A. The effect of etomidate on adrenal function in critical illness: a systematic review. Intensive Care Medicine, 2011.PMID 21373823