Anaes SAQs · Anaesthetic adjuncts
Pharmacology of fentanyl
Short-answer question on fentanyl pharmacokinetics, context-sensitive half-time and comparison with morphine.
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Prompt
Describe the pharmacokinetics of fentanyl, explain the concept of context-sensitive half-time, and compare fentanyl with morphine.
Question
Describe the pharmacokinetics of fentanyl, explain the concept of context-sensitive half-time, and compare fentanyl with morphine.
References7ShowHide
- [1]Ramos-Matos CF, et al. Fentanyl StatPearls, 2023.PMID 29083586
- [2]Patocka J, et al. Fentanyl and its derivatives: Pain-killers or man-killers? Heliyon, 2024.PMID 38644874
- [3]Bowdle TA Adverse effects of opioid agonists and agonist-antagonists in anaesthesia Drug Saf, 1998.PMID 9747665
- [4]Baldo BA, et al. Opioid toxicity: histamine, hypersensitivity, and MRGPRX2 Arch Toxicol, 2023.PMID 36344690
- [5]Feierman DE, et al. Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4 Drug Metab Dispos, 1996.PMID 8886601
- [6]Hughes MA, et al. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs Anesthesiology, 1992.PMID 1539843
- [7]Egan TD Remifentanil pharmacokinetics and pharmacodynamics. A preliminary appraisal Clin Pharmacokinet, 1995.PMID 7586903