Sickle cell disease (SCD) is an autosomal recessive haemoglobinopathy caused by a single glutamic-acid-to-valine substitution at position 6 of beta-globin (Glu6Val, HBB on chromosome 11p15.5) producing haemoglobin S (HbS), which polymerises under deoxygenation into rigid fibres that distort the red cell into a sickle. Full topic, figures, and citations: https://medvellum.com/topics/sickle-cell-disease References Kato 2018 · Nat Rev Dis Primers Yawn 2014 · JAMA Educational content only. Not medical advice. Not a substitute for current guidelines or senior clinical judgement. MedVellum — evi…
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