Psych Vivas · Emergency psychiatry
Overdose and toxicology — structured clinical viva
Fellowship viva on relative toxicity of venlafaxine vs SSRIs, always-screen paracetamol, seizure management, observation, and post-OD risk assessment.
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Interpretation
Reveal interpretation
Reject premature transfer. Venlafaxine is not risk-equivalent to many SSRIs in overdose; relative toxicity data place it closer to higher-risk agents for seizures and serious outcomes. She already seized — she needs medical observation, monitoring, and toxin work-up, not an immediate psych-ward bed.[1][2][5]
Immediate priorities. ABCDE, continuous monitoring, glucose, ECG serial review, benzodiazepines for recurrent seizures, timed paracetamol level and NAC if indicated, basic labs, early toxicology advice. Airway vigilance if GCS falls.[3][4]
Disposition thinking. Observe through expected peak effects; escalate to ICU if status epilepticus, airway compromise, or progressive cardiotoxicity. Only after medical clearance: structured suicide risk assessment, means restriction (dispose stock, safer future prescribing), and least-restrictive safe psychiatric plan.[4]
You have read the opening of this viva. The complete unit — every section and its primary-source references — is part of the Psychiatry Fellowship fellowship atlas.
References5Show ledgerHide ledger
- [1]Whyte IM, Dawson AH, Buckley NA Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants. QJM, 2003.PMID 12702786
- [2]Isbister GK, Bowe SJ, Dawson A, et al. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol, 2004.PMID 15362595
- [3]Bateman DN, Dart RC, Dear JW, et al. Fifty years of paracetamol (acetaminophen) poisoning: the development of risk assessment and treatment 1973-2023 with particular focus on contributions published from Edinburgh and Denver. Clin Toxicol (Phila), 2023.PMID 38197864
- [4]Parris MA, Calello DP Found Down: Approach to the Patient with an Unknown Poisoning. Emerg Med Clin North Am, 2022.PMID 35461619
- [5]Brett J, Wylie CE, Raubenheimer J, Isbister GK, et al. The relative lethal toxicity of pharmaceutical and illicit substances: a 16-year study of the Greater Newcastle Hunter Area, Australia. Br J Clin Pharmacol, 2019.PMID 31173392