Psych Vivas · Psychopharmacology — monoamine oxidase inhibitors
Monoamine oxidase inhibitors — consultant viva
Fellowship viva covering MAOI classification, tyramine, washouts, serotonin toxicity combinations, selegiline patch diet rules, and TRD evidence.
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Study tools
Target exams
FRANZCPMRCPsychABPNMD-DNB
Prompt
Examiner places cards: phenelzine, cheese reaction, fluoxetine washout, pethidine, selegiline 6 vs 12 mg patch, STAR*D level 4, atypical depression, moclobemide RIMA.
Station structure
Time: 8–10 minutes. Depth: consultant teaching registrar. Expect isoform logic, washout numbers, and clear separation of cheese reaction from serotonin toxicity without inventing universal dose tables that contradict product labels.[1][7]
References8ShowHide
- [1]Van den Eynde V, Abdelmoemin WR, Abraham MM, et al. The prescriber's guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression CNS Spectr, 2023.PMID 35837681
- [2]Liebowitz MR, Quitkin FM, Stewart JW, et al. Antidepressant specificity in atypical depression Arch Gen Psychiatry, 1988.PMID 3276282
- [3]McGrath PJ, Stewart JW, Fava M, et al. Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report Am J Psychiatry, 2006.PMID 16946177
- [4]Bodkin JA, Amsterdam JD Transdermal selegiline in major depression: a double-blind, placebo-controlled, parallel-group study in outpatients Am J Psychiatry, 2002.PMID 12411221
- [5]Amsterdam JD A double-blind, placebo-controlled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder J Clin Psychiatry, 2003.PMID 12633131
- [6]Gillman PK Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity Br J Anaesth, 2005.PMID 16051647
- [7]Van den Eynde V, Gillman PK, Blackwell BB The Prescriber's Guide to the MAOI Diet-Thinking Through Tyramine Troubles Psychopharmacol Bull, 2022.PMID 35721816
- [8]Lotufo-Neto F, Trivedi M, Thase ME Meta-analysis of the reversible inhibitors of monoamine oxidase type A moclobemide and brofaromine for the treatment of depression Neuropsychopharmacology, 1999.PMID 10063483