Psych Vivas · Psychopharmacology — lamotrigine
Lamotrigine — consultant viva
Fellowship viva covering polarity evidence, titration tables, SJS stop rules, valproate and OCP interactions, restarts, and pregnancy counselling.
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Study tools
Target exams
FRANZCPMRCPsychABPNMD-DNB
Prompt
Examiner places cards: Goodwin pooled, 25→50 titration, valproate, combined OCP, day-12 mucosal rash, missed doses 10 days, pregnancy EURAP.
Station structure
Time: 8–10 minutes. Depth: consultant teaching registrar. Expect named trials, product-table titration logic, and automatic SCAR stop rules without inventing exact national tablet strengths as universal law.[1][7][10]
References10ShowHide
- [1]Goodwin GM, Bowden CL, Calabrese JR, et al. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder J Clin Psychiatry, 2004.PMID 15096085
- [2]Bowden CL, Calabrese JR, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder Arch Gen Psychiatry, 2003.PMID 12695317
- [3]Calabrese JR, Bowden CL, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder J Clin Psychiatry, 2003.PMID 14628976
- [4]Geddes JR, Calabrese JR, Goodwin GM Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials Br J Psychiatry, 2009.PMID 19118318
- [5]Yuen AW, Land G, Weatherley BC, et al. Sodium valproate acutely inhibits lamotrigine metabolism Br J Clin Pharmacol, 1992.PMID 1524964
- [6]Sabers A, Ohman I, Christensen J, et al. Oral contraceptives reduce lamotrigine plasma levels Neurology, 2003.PMID 12939444
- [7]Guberman AH, Besag FM, Brodie MJ, et al. Lamotrigine-associated rash: risk/benefit considerations in adults and children Epilepsia, 1999.PMID 10403224
- [8]Tomson T, Battino D, Bonizzoni E, et al. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry Lancet Neurol, 2018.PMID 29680205
- [9]Messenheimer JA, Guberman AH Rash with lamotrigine: dosing guidelines Epilepsia, 2000.PMID 10756418
- [10]Yatham LN, Kennedy SH, Parikh SV, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder Bipolar Disord, 2018.PMID 29536616