Psych Vivas · Psychopharmacology — first-generation antipsychotics
First-generation antipsychotics — consultant viva
Fellowship viva covering FGA classification, landmark trials, receptor map, EPS/NMS emergencies, TD risk, depot use and treatment-resistance pathway.
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Study tools
Target exams
FRANZCPMRCPsychABPNMD-DNB
Prompt
Examiner places cards: CATIE perphenazine, CUtLASS QoL, EUFEST FEP, high vs low potency, D2 ~80% EPS zone, Barnes akathisia, Carbon TD, NMS, oil depot, TRRIP clozapine.
Station structure
Time: 8–10 minutes. Depth: consultant teaching registrar. Expect named trials, potency map, occupancy teaching, emergency EPS/NMS steps, Carbon TD nuance, and TRRIP — not undergraduate “typicals cause EPS” only.[1][2][3][6][8]
References8ShowHide
- [1]Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia N Engl J Med, 2005.PMID 16172203
- [2]Jones PB, Barnes TR, Davies L, et al. Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1) Arch Gen Psychiatry, 2006.PMID 17015810
- [3]Kahn RS, Fleischhacker WW, Boter H, et al. Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial Lancet, 2008.PMID 18374841
- [4]Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis Lancet, 2013.PMID 23810019
- [5]Kapur S, Seeman P Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis Am J Psychiatry, 2001.PMID 11229973
- [6]Carbon M, Kane JM, Leucht S, Correll CU Tardive dyskinesia risk with first- and second-generation antipsychotics in comparative randomized controlled trials: a meta-analysis World Psychiatry, 2018.PMID 30192088
- [7]Barnes TR A rating scale for drug-induced akathisia Br J Psychiatry, 1989.PMID 2574607
- [8]Howes OD, McCutcheon R, Agid O, et al. Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology Am J Psychiatry, 2017.PMID 27919182