Psych Vivas · Old age psychiatry — dementia neuropsychiatry
BPSD — structured clinical viva
Fellowship viva on long-term antipsychotic use in BPSD, black-box harms, deprescribing, and non-drug care with landmark trial integration.
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Interpretation
Reveal interpretationShowHide
This is chronic antipsychotic exposure for BPSD without clear ongoing severe risk, now with sedation and falls risk. Re-describe the original target symptom and current behaviour with ABC/DICE; exclude pain, constipation, infection and environmental triggers for residual shower resistance; screen for EPS, orthostasis and oversedation. Nine months without structured review is already a red flag. [1]
Evidence framing for family. Schneider meta-analysis: atypical antipsychotics increase death risk versus placebo in dementia RCTs. CATIE-AD: limited effectiveness and frequent discontinuation. DART-AD long-term: continued neuroleptics associated with higher mortality — the tablet is not a harmless "calm forever" medicine. Devanand: among responders, stopping risperidone can increase relapse — so taper carefully with monitoring rather than abrupt cessation if prior severe psychosis/aggression. [2][3][4][5]
Plan. Optimise non-drug personal-care strategies and pain management (Husebo). Gradual dose reduction (e.g. reduce by 25–50% every 1–2 weeks) toward stop if stable, with staff education on relapse signs and criteria to restart a low dose. Document risk–benefit discussion with substitute decision-maker. [1][6]
References6ShowHide
- [1]Kales HC, Gitlin LN, Lyketsos CG Assessment and management of behavioral and psychological symptoms of dementia BMJ, 2015.PMID 25731881
- [2]Schneider LS, Dagerman KS, Insel P Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials JAMA, 2005.PMID 16234500
- [3]Schneider LS, Tariot PN, Dagerman KS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease N Engl J Med, 2006.PMID 17035647
- [4]Ballard C, Hanney ML, Theodoulou M, et al. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomised placebo-controlled trial Lancet Neurol, 2009.PMID 19138567
- [5]Devanand DP, Mintzer J, Schultz SK, et al. Relapse risk after discontinuation of risperidone in Alzheimer's disease N Engl J Med, 2012.PMID 23075176
- [6]Husebo BS, Ballard C, Sandvik R, et al. Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial BMJ, 2011.PMID 21765198