Psych Vivas · Psychopharmacology — antidepressants
Antidepressants — cross-table viva
Fellowship viva on antidepressant mechanisms, landmark evidence, safety emergencies, switching/washouts, and augmentation.
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Study tools
Target exams
FRANZCPMRCPsychABPNMD-DNB
Prompt
Examiner draws three columns: Class / Target / Killer side-effect. Then places cards: STAR*D, Cipriani 2018, Hunter criteria, Montejo, Movig, Geddes, lithium aug, T3, atypical AP aug.
Station structure
Time: 8–10 minutes. Depth: consultant teaching registrar. Expect mechanism maps, trial one-liners, dose ranges, and safety without marketing slogans.[2]
References9ShowHide
- [1]Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report Am J Psychiatry, 2006.PMID 17074942
- [2]Cipriani A, Furukawa TA, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis Lancet, 2018.PMID 29477251
- [3]Dunkley EJ, Isbister GK, Sibbritt D, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity QJM, 2003.PMID 12925718
- [4]Boyer EW, Shannon M The serotonin syndrome N Engl J Med, 2005.PMID 15784664
- [5]Crossley NA, Bauer M Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials J Clin Psychiatry, 2007.PMID 17592920
- [6]Nelson JC, Papakostas GI Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials Am J Psychiatry, 2009.PMID 19687129
- [7]Geddes JR, Carney SM, Davies C, et al. Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review Lancet, 2003.PMID 12606176
- [8]Montejo AL, Llorca G, Izquierdo JA, et al. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients J Clin Psychiatry, 2001.PMID 11229449
- [9]Movig KL, Leufkens HG, Lenderink AW, et al. Association between antidepressant drug use and hyponatraemia: a case-control study Br J Clin Pharmacol, 2002.PMID 11966666