Psych · Psychopharmacology — stimulants and ADHD medications
Stimulants and ADHD medications
Also known as ADHD stimulants · Methylphenidate · Amphetamines ADHD · Lisdexamfetamine · Atomoxetine · Guanfacine · Clonidine ADHD · ADHD pharmacotherapy
Exam-exhaustive fellowship pharmacology of ADHD medications — methylphenidate and amphetamine formulations with doses and monitoring, atomoxetine, guanfacine and clonidine, DAT/NET mechanisms, MTA and Cortese NMA, cardiovascular safety (Cooper/Habel/Hennissen/Farhat), diversion and misuse, switching, adult versus child pathways. FRANZCP-primary, globally tagged.
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Meet the patient
A 14-year-old boy is referred because his teachers say he "cannot concentrate". His mother wants "something for his ADHD". He has had no structured assessment, sleeps five hours a night on his phone, and his father was hospitalised last year for a stimulant-induced psychotic episode.[22][24]
The exam question this vignette plants is the one that fails stations: before you reach for a controlled drug, what must be true? A multi-informant, multi-setting diagnosis; sleep, anxiety, learning disorder and bipolar spectrum excluded or named; cardiac and family history taken; and a diversion risk plan. This topic is the prescribing spine behind that decision.[3][22][24]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Psychiatry Fellowship fellowship atlas.
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- [1]The MTA Cooperative Group A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD Arch Gen Psychiatry, 1999.PMID 10591283
- [2]Molina BSG, Hinshaw SP, Swanson JM, et al. The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study J Am Acad Child Adolesc Psychiatry, 2009.PMID 19318991
- [3]Cortese S, Adamo N, Del Giovane C, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis Lancet Psychiatry, 2018.PMID 30097390
- [4]Volkow ND, Wang G, Fowler JS, et al. Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain J Neurosci, 2001.PMID 11160455
- [5]Michelson D, Allen AJ, Busner J, et al. Once-daily atomoxetine treatment for children and adolescents with attention deficit hyperactivity disorder: a randomized, placebo-controlled study Am J Psychiatry, 2002.PMID 12411225
- [6]Michelson D, Adler L, Spencer T, et al. Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies Biol Psychiatry, 2003.PMID 12547466
- [7]Newcorn JH, Kratochvil CJ, Allen AJ, et al. Atomoxetine and osmotically released methylphenidate for the treatment of attention deficit hyperactivity disorder: acute comparison and differential response Am J Psychiatry, 2008.PMID 18281409
- [8]Sallee FR, McGough J, Wigal T, et al. Guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder: a placebo-controlled trial J Am Acad Child Adolesc Psychiatry, 2009.PMID 19106767
- [9]Jain R, Segal S, Kollins SH, et al. Clonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorder J Am Acad Child Adolesc Psychiatry, 2011.PMID 21241954
- [10]Kollins SH, Jain R, Brams M, et al. Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD Pediatrics, 2011.PMID 21555501
- [11]Wilens TE, Faraone SV, Biederman J, et al. Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature Pediatrics, 2003.PMID 12509574
- [12]Wilens TE Attention deficit hyperactivity disorder and substance use disorders Am J Psychiatry, 2006.PMID 17151154
- [13]Adler LA, Zimmerman B, Starr HL, et al. Efficacy and safety of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled, double-blind, parallel group, dose-escalation study J Clin Psychopharmacol, 2009.PMID 19440077
- [14]Spencer T, Biederman J, Wilens T, et al. Efficacy of a mixed amphetamine salts compound in adults with attention-deficit/hyperactivity disorder Arch Gen Psychiatry, 2001.PMID 11483144
- [15]Biederman J, Boellner SW, Childress A, et al. Lisdexamfetamine dimesylate and mixed amphetamine salts extended-release in children with ADHD: a double-blind, placebo-controlled study Biol Psychiatry, 2007.PMID 17631866
- [16]Cooper WO, Habel LA, Sox CM, et al. ADHD drugs and serious cardiovascular events in children and young adults N Engl J Med, 2011.PMID 22043968
- [17]Habel LA, Cooper WO, Sox CM, et al. ADHD medications and risk of serious cardiovascular events in young and middle-aged adults JAMA, 2011.PMID 22161946
- [18]Hennissen L, Bakker MJ, Banaschewski T, et al. Cardiovascular Effects of Stimulant and Non-Stimulant Medication for Children and Adolescents with ADHD: A Systematic Review and Meta-Analysis of Trials of Methylphenidate, Amphetamines and Atomoxetine CNS Drugs, 2017.PMID 28236285
- [19]Farhat LC, Lannes A, Del Giovane C, et al. Comparative cardiovascular safety of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis Lancet Psychiatry, 2025.PMID 40203844
- [20]Graham J, Banaschewski T, Buitelaar J, et al. European guidelines on managing adverse effects of medication for ADHD Eur Child Adolesc Psychiatry, 2011.PMID 21042924
- [21]Cortese S, Holtmann M, Banaschewski T, et al. Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents J Child Psychol Psychiatry, 2013.PMID 23294014
- [22]Pliszka S; AACAP Work Group on Quality Issues Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder J Am Acad Child Adolesc Psychiatry, 2007.PMID 17581453
- [23]Kooij SJ, Bejerot S, Blackwell A, et al. European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD BMC Psychiatry, 2010.PMID 20815868
- [24]Kooij JJS, Bijlenga D, Salerno L, et al. Updated European Consensus Statement on diagnosis and treatment of adult ADHD Eur Psychiatry, 2019.PMID 30453134
- [25]Faraone SV, Glatt SJ A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes J Clin Psychiatry, 2010.PMID 20051220
- [26]Adler LA, Spencer TJ, Williams DW, et al. Long-term, open-label safety and efficacy of atomoxetine in adults with ADHD: final report of a 4-year study J Atten Disord, 2008.PMID 18448861
- [27]Childress AC, Sallee FR Attention-deficit/hyperactivity disorder with inadequate response to stimulants: approaches to management CNS Drugs, 2014.PMID 24402970
- [28]Molina BSG, Kennedy TM, Howard AL, et al. Association Between Stimulant Treatment and Substance Use Through Adolescence Into Early Adulthood JAMA Psychiatry, 2023.PMID 37405756