Psych · Old age psychiatry — falls polypharmacy frailty
Falls, polypharmacy and frailty in old-age psychiatry
Also known as Falls in older adults psychiatry · Polypharmacy old-age psychiatry · Frailty and psychotropics · Fall-risk-increasing drugs FRIDs · Deprescribing frail elderly psychiatry · Geriatric falls medication review · Psychotropics and falls
Exam-exhaustive fellowship reference on falls, polypharmacy and frailty in old-age psychiatry — Fried vs Rockwood frailty, FRID psychotropics, Beers and STOPP/START, multifactorial falls prevention, deprescribing, safe late-life prescribing under frailty. FRANZCP-primary, globally tagged.
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Target exams
Red flags
- New or recurrent falls after starting or escalating benzodiazepines, Z-drugs, antipsychotics, or sedating antidepressants — treat as FRID harm until reviewed
- Open-ended antipsychotic for mild BPSD or wandering in a frail resident with prior falls — mortality and stroke risk plus fall cascade
- Acute confusion, falls, or seizures after SSRI/SNRI start — check sodium urgently for SIADH
- Syncope or near-syncope on QT-prolonging psychotropic polypharmacy — emergency pathway, not 'another mechanical fall'
- Chronic temazepam or Z-drug in frail older adult with recurrent falls and no deprescribing plan
- Start-low-stay-low under-treatment of severe late-life depression solely because of fall anxiety
Meet the patient
An 82-year-old woman in residential aged care is found on the floor at 3am, third time in six weeks. The incident form says mechanical fall, no injury, staff to increase supervision.[10]
Her chart holds temazepam nightly for nine years, risperidone started four months ago for calling out, sertraline increased a fortnight ago, and oxybutynin nobody can account for. Her sodium has not been checked since the sertraline went up.[4][5][7]
Two questions decide the whole answer. Which of these falls is the medication doing? And what do I stop first without destabilising her? Everything below exists to answer those two.[5][13]
Etymology worth one line in a viva: iatrogenic is Greek — iatros (healer) plus genes (produced by). Literally: brought about by the doctor. Nowhere in medicine is the word more literal than a psychotropic fall, and nowhere is it more fixable.[4][5][16]
References16ShowHide
- [1]Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype J Gerontol A Biol Sci Med Sci, 2001.PMID 11253156
- [2]Rockwood K, Mitnitski A Frailty in relation to the accumulation of deficits J Gerontol A Biol Sci Med Sci, 2007.PMID 17634318
- [3]Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K Frailty in elderly people Lancet, 2013.PMID 23395245
- [4]Woolcott JC, Richardson KJ, Wiens MO, Patel B, Marin J, Khan KM, Marra CA Meta-analysis of the impact of 9 medication classes on falls in elderly persons Arch Intern Med, 2009.PMID 19933955
- [5]Seppala LJ, Wermelink AMAT, de Vries M, Ploegmakers KJ, van de Glind EMM, Daams JG, et al. Fall-Risk-Increasing Drugs: A Systematic Review and Meta-Analysis: II. Psychotropics J Am Med Dir Assoc, 2018.PMID 29402652
- [6]Glass J, Lanctôt KL, Herrmann N, Sproule BA, Busto UE Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits BMJ, 2005.PMID 16284208
- [7]By the 2023 American Geriatrics Society Beers Criteria Update Expert Panel American Geriatrics Society 2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults J Am Geriatr Soc, 2023.PMID 37139824
- [8]O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, Gallagher P STOPP/START criteria for potentially inappropriate prescribing in older people: version 2 Age Ageing, 2015.PMID 25324330
- [9]O'Mahony D, Cherubini A, Guiteras AR, Denkinger M, Beuscart JB, Onder G, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 3 Eur Geriatr Med, 2023.PMID 37256475
- [10]Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society Summary of the Updated American Geriatrics Society/British Geriatrics Society clinical practice guideline for prevention of falls in older persons J Am Geriatr Soc, 2011.PMID 21226685
- [11]Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE Interventions for preventing falls in older people living in the community Cochrane Database Syst Rev, 2012.PMID 22972103
- [12]Hopewell S, Adedire O, Copsey BJ, Boniface GJ, Sherrington C, Clemson L, et al. Multifactorial and multiple component interventions for preventing falls in older people living in the community Cochrane Database Syst Rev, 2018.PMID 30035305
- [13]Scott IA, Hilmer SN, Reeve E, Potter K, Le Couteur D, Rigby D, et al. Reducing inappropriate polypharmacy: the process of deprescribing JAMA Intern Med, 2015.PMID 25798731
- [14]Reeve E, Gnjidic D, Long J, Hilmer S A systematic review of the emerging definition of 'deprescribing' with network analysis: implications for future research and clinical practice Br J Clin Pharmacol, 2015.PMID 27006985
- [15]Schneider LS, Dagerman KS, Insel P Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials JAMA, 2005.PMID 16234500
- [16]Mangoni AA, Jackson SHD Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications Br J Clin Pharmacol, 2004.PMID 14678335