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Psych TopicsGeneral adult psychiatry — perinatal

Psych · General adult psychiatry — perinatal

Perinatal mood and anxiety disorders

Also known as PMAD · Postnatal depression · Postpartum depression · Antenatal depression · Postpartum psychosis · Perinatal OCD · Puerperal psychosis · Peripartum depression

Exam-exhaustive fellowship reference on perinatal mood and anxiety disorders — antenatal and postnatal depression, postpartum psychosis, perinatal anxiety and OCD, bonding, suicide and infanticide risk assessment principles, safe prescribing in pregnancy and lactation, ECT, mother-baby units, and safeguarding. FRANZCP-primary, globally tagged.

high25 referencesUpdated 25 July 202613 min readVerification in progress

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FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Postpartum psychosis or new mania/mixed state after birth — psychiatric emergency; same-day senior review, secure setting, infant safety plan
  • Active suicidal intent or plan in the perinatal period — intensify care; maternal suicide is a leading cause of late maternal death in high-resource settings
  • Ego-syntonic delusions or command hallucinations involving harm to the infant — treat as psychosis pathway with safeguarding, not as 'normal anxiety'
  • Inability to care for the infant safely, severe neglect risk, or filicide ideation with intent — escalate setting and multi-agency safeguarding
  • Abrupt cessation of effective mood stabiliser or antidepressant at conception without risk-benefit plan — relapse risk may exceed medication risk
  • Valproate exposure in pregnancy-capable patients without exceptional safeguards — major teratogen; avoid and counsel
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Your progress

Saved on this device.

Practise this topic12 MCQs with explanations

Target exams

FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Postpartum psychosis or new mania/mixed state after birth — psychiatric emergency; same-day senior review, secure setting, infant safety plan
  • Active suicidal intent or plan in the perinatal period — intensify care; maternal suicide is a leading cause of late maternal death in high-resource settings
  • Ego-syntonic delusions or command hallucinations involving harm to the infant — treat as psychosis pathway with safeguarding, not as 'normal anxiety'
  • Inability to care for the infant safely, severe neglect risk, or filicide ideation with intent — escalate setting and multi-agency safeguarding
  • Abrupt cessation of effective mood stabiliser or antidepressant at conception without risk-benefit plan — relapse risk may exceed medication risk
  • Valproate exposure in pregnancy-capable patients without exceptional safeguards — major teratogen; avoid and counsel
The one-line answer

Perinatal mood and anxiety disorders run from baby blues (days, self-limiting) through perinatal depression, anxiety and OCD (weeks to months, treatable) to postpartum psychosis (the first fortnight, an emergency). Every answer needs the same spine: two patients assessed in parallel, measurement-based stepped care, risk-benefit prescribing in pregnancy and lactation, mother-baby unit access for severe illness, and the discriminator that decides the pathway — ego-dystonic intrusions are not ego-syntonic delusions.[5][7][3]

Meet the patient

Eleven weeks postpartum. She scores 19 on the EPDS at her maternal and child health check, endorses the self-harm item, and tells the nurse she is "just tired." Her partner says she has not laughed since the birth and will not be left alone with the baby "in case."[2][7]

In the room she is flat, guilty, and precise: she loves her son, she is convinced she is ruining him, and she has thought about walking into traffic on the way to this appointment.[7][11]

Two questions decide everything in the next ten minutes. Is this depression, or is it psychosis? And who is caring for the infant tonight?[5][10]

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References25ShowHide
  1. [1]Gavin NI, Gaynes BN, Lohr KN, Meltzer-Brody S, Gartlehner G, Swinson T Perinatal depression: a systematic review of prevalence and incidence Obstet Gynecol, 2005.PMID 16260528
  2. [2]Cox JL, Holden JM, Sagovsky R Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale Br J Psychiatry, 1987.PMID 3651732
  3. [3]Malhi GS, Bell E, Bassett D, Boyce P, Bryant R, Hazell P, et al. The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders Aust N Z J Psychiatry, 2021.PMID 33353391
  4. [4]Bergink V, Bouvy PF, Vervoort JS, Koorengevel KM, Steegers EA, Kushner SA Prevention of postpartum psychosis and mania in women at high risk Am J Psychiatry, 2012.PMID 22407083
  5. [5]Bergink V, Rasgon N, Wisner KL Postpartum Psychosis: Madness, Mania, and Melancholia in Motherhood Am J Psychiatry, 2016.PMID 27609245
  6. [6]Wesseloo R, Kamperman AM, Munk-Olsen T, Pop VJ, Kushner SA, Bergink V Risk of Postpartum Relapse in Bipolar Disorder and Postpartum Psychosis: A Systematic Review and Meta-Analysis Am J Psychiatry, 2016.PMID 26514657
  7. [7]Howard LM, Molyneaux E, Dennis CL, Rochat T, Stein A, Milgrom J Non-psychotic mental disorders in the perinatal period Lancet, 2014.PMID 25455248
  8. [8]Jones I, Chandra PS, Dazzan P, Howard LM Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period Lancet, 2014.PMID 25455249
  9. [9]Stein A, Pearson RM, Goodman SH, Rapa E, Rahman A, McCallum M, et al. Effects of perinatal mental disorders on the fetus and child Lancet, 2014.PMID 25455250
  10. [10]Howard LM, Khalifeh H Perinatal mental health: a review of progress and challenges World Psychiatry, 2020.PMID 32931106
  11. [11]Chesney E, Goodwin GM, Fazel S Risks of all-cause and suicide mortality in mental disorders: a meta-review World Psychiatry, 2014.PMID 24890068
  12. [12]Yonkers KA, Forray A, Smith MV Maternal Antidepressant Use and Pregnancy Outcomes JAMA, 2017.PMID 28810017
  13. [13]Bergink V, Burgerhout KM, Koorengevel KM, Kamperman AM, Hoogendijk WJ, Lambregtse-van den Berg MP, et al. Treatment of psychosis and mania in the postpartum period Am J Psychiatry, 2015.PMID 25640930
  14. [14]UK ECT Review Group Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis Lancet, 2003.PMID 12642045
  15. [15]Kroenke K, Spitzer RL, Williams JB The PHQ-9: validity of a brief depression severity measure J Gen Intern Med, 2001.PMID 11556941
  16. [16]Woody CA, Ferrari AJ, Siskind DJ, Whiteford HA, Harris MG A systematic review and meta-regression of the prevalence and incidence of perinatal depression J Affect Disord, 2017.PMID 28531848
  17. [17]Munk-Olsen T, Laursen TM, Pedersen CB, Mors O, Mortensen PB New parents and mental disorders: a population-based register study JAMA, 2006.PMID 17148723
  18. [18]Patorno E, Huybrechts KF, Hernandez-Diaz S Lithium Use in Pregnancy and the Risk of Cardiac Malformations N Engl J Med, 2017.PMID 28854098
  19. [19]Weissman AM, Levy BT, Hartz AJ, Bentler S, Donohue M, Ellingrod VL, et al. Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants Am J Psychiatry, 2004.PMID 15169695
  20. [20]Galbally M, Sved-Williams A, Kristianopulos D, Mercuri K, Brown P, Buist A Comparison of public mother-baby psychiatric units in Australia: similarities, strengths and recommendations Australas Psychiatry, 2019.PMID 30407072
  21. [21]Gao SY, Wu QJ, Sun C, Zhang TN, Shen ZQ, Liu CX, et al. Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births BMC Med, 2018.PMID 30415641
  22. [22]Speisman BB, Storch EA, Abramowitz JS Postpartum obsessive-compulsive disorder J Obstet Gynecol Neonatal Nurs, 2011.PMID 22092284
  23. [23]Fairbrother N, Abramowitz JS New parenthood as a risk factor for the development of obsessional problems Behav Res Ther, 2007.PMID 17084810
  24. [24]Kellner CH Electroconvulsive Therapy (ECT) for Postpartum Psychosis: Treatment for a Medical Emergency Am J Psychiatry, 2025.PMID 41320827
  25. [25]Cuijpers P, Quero S, Noma H, Ciharova M, Miguel C, Karyotaki E, et al. Psychotherapies for depression: a network meta-analysis covering efficacy, acceptability and long-term outcomes of all main treatment types World Psychiatry, 2021.PMID 34002502

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