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Psych TopicsGeneral adult psychiatry — personality disorders

Psych · General adult psychiatry — personality disorders

Cluster A and Cluster C personality disorders

Also known as Paranoid personality disorder · Schizoid personality disorder · Schizotypal personality disorder · Avoidant personality disorder · Dependent personality disorder · Obsessive-compulsive personality disorder · OCPD · Anankastic personality disorder · Cluster A · Cluster C

Exam-exhaustive fellowship reference on Cluster A (paranoid, schizoid, schizotypal) and Cluster C (avoidant, dependent, OCPD) personality disorders — DSM-5-TR criteria, ICD-11 severity and trait domains, epidemiology, mechanisms, differentials (ASD, social anxiety, OCD, schizophrenia spectrum), assessment, psychotherapy and limited pharmacotherapy, prognosis. FRANZCP-primary, globally tagged.

medium20 referencesUpdated 25 July 202615 min readVerification in progress

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FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Late-onset personality change with cognitive, neurological or systemic red flags — investigate organic disease before locking a lifelong PD label
  • Schizotypal deterioration with frank delusions, hallucinations or marked functional collapse — treat on a psychosis pathway, do not dismiss as 'just personality'
  • Acute paranoid crisis with risk of violence, retaliatory planning, or total treatment refusal when capacity is impaired — safety and legal duties first
  • Dependent patient in an exploitative or abusive relationship — safeguarding (adult/child) is part of the psychiatric plan
  • Missed OCD, social anxiety disorder, autism spectrum disorder, or major depression while attributing all morbidity to personality
  • Unreviewed polypharmacy for 'oddness' or chronic anxiety without a formulation, target symptom, or stop date
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Practise this topic10 MCQs with explanations

Target exams

FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Late-onset personality change with cognitive, neurological or systemic red flags — investigate organic disease before locking a lifelong PD label
  • Schizotypal deterioration with frank delusions, hallucinations or marked functional collapse — treat on a psychosis pathway, do not dismiss as 'just personality'
  • Acute paranoid crisis with risk of violence, retaliatory planning, or total treatment refusal when capacity is impaired — safety and legal duties first
  • Dependent patient in an exploitative or abusive relationship — safeguarding (adult/child) is part of the psychiatric plan
  • Missed OCD, social anxiety disorder, autism spectrum disorder, or major depression while attributing all morbidity to personality
  • Unreviewed polypharmacy for 'oddness' or chronic anxiety without a formulation, target symptom, or stop date
One-line fellowship answer

Cluster A (paranoid, schizoid, schizotypal) and Cluster C (avoidant, dependent, OCPD) are enduring patterns of self and interpersonal dysfunction diagnosed longitudinally — DSM-5-TR criterion counts or ICD-11 severity plus trait domains. Management is alliance-first psychotherapy (CBT, schema therapy, adapted psychodynamic and supportive work), systematic discrimination from ASD, social anxiety, OCD and schizophrenia-spectrum illness, treatment of comorbidity, and only time-limited symptom-targeted medication — never polypharmacy as a substitute for formulation.[5][7][12][20]

Meet the patient

A 38-year-old surgeon is referred by his own department head. He stays three hours after every list rewriting his registrars' notes. He cannot delegate a discharge summary because "nobody else meets the standard." His wife has stopped attending his dinners. He presents, politely, to ask why everyone around him has such low standards — and he genuinely wants an answer.[16][17]

The examiner's question is not "does he have OCD?" It is: "Why is this not OCD, and what treatment do you offer a man who thinks he is right?" That answer is this topic.[14][15]

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References20ShowHide
  1. [1]Torgersen S, Kringlen E, Cramer V The prevalence of personality disorders in a community sample Arch Gen Psychiatry, 2001.PMID 11386989
  2. [2]Lenzenweger MF, Lane MC, Loranger AW, Kessler RC DSM-IV personality disorders in the National Comorbidity Survey Replication Biol Psychiatry, 2007.PMID 17217923
  3. [3]Grant BF, Hasin DS, Stinson FS, Dawson DA, et al. Prevalence, correlates, and disability of personality disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions J Clin Psychiatry, 2004.PMID 15291684
  4. [4]Shadid J, Ferrari AJ, Bach B, Sellbom M, et al. The global epidemiology of personality disorder: a systematic review and meta-regression Lancet Psychiatry, 2025.PMID 41197646
  5. [5]Bamelis LL, Evers SM, Spinhoven P, Arntz A Results of a multicenter randomized controlled trial of the clinical effectiveness of schema therapy for personality disorders Am J Psychiatry, 2014.PMID 24322378
  6. [6]Bamelis LL, Arntz A, Wetzelaer P, Verdoorn R, et al. Economic evaluation of schema therapy and clarification-oriented psychotherapy for personality disorders: a multicenter, randomized controlled trial J Clin Psychiatry, 2015.PMID 26579561
  7. [7]Kirchner SK, Roeh A, Nolden J, Hasan A Diagnosis and treatment of schizotypal personality disorder: evidence from a systematic review NPJ Schizophr, 2018.PMID 30282970
  8. [8]Rosell DR, Futterman SE, McMaster A, Siever LJ Schizotypal personality disorder: a current review Curr Psychiatry Rep, 2014.PMID 24828284
  9. [9]Cheli S, Wisepape CN, Witten CDY, Floridi M, et al. Psychosocial and pharmacological interventions for cluster a personality disorders: A systematic review and two exploratory meta-analyses Personal Disord, 2025.PMID 40111791
  10. [10]Jakobsen KD, Skyum E, Hashemi N, Schjerning O, et al. Antipsychotic treatment of schizotypy and schizotypal personality disorder: a systematic review J Psychopharmacol, 2017.PMID 28347257
  11. [11]Gundersen KB, Arnfred B, Albert N, Rasmussen AR, et al. Treatment of schizotypal disorder: A systematic review and GRADE evaluation of the certainty of evidence Schizophr Res, 2026.PMID 41421074
  12. [12]Lampe L, Malhi GS Avoidant personality disorder: current insights Psychol Res Behav Manag, 2018.PMID 29563846
  13. [13]Frandsen FW, Simonsen S, Poulsen S, Sørensen P, et al. Social anxiety disorder and avoidant personality disorder from an interpersonal perspective Psychol Psychother, 2020.PMID 30656823
  14. [14]Pozza A, Starcevic V, Ferretti F, Pedani C, et al. Obsessive-Compulsive Personality Disorder Co-occurring in Individuals with Obsessive-Compulsive Disorder: A Systematic Review and Meta-analysis Harv Rev Psychiatry, 2021.PMID 33666394
  15. [15]Mancebo MC, Eisen JL, Grant JE, Rasmussen SA Obsessive compulsive personality disorder and obsessive compulsive disorder: clinical characteristics, diagnostic difficulties, and treatment Ann Clin Psychiatry, 2005.PMID 16402751
  16. [16]Pinto A, Teller J, Wheaton MG Obsessive-Compulsive Personality Disorder: A Review of Symptomatology, Impact on Functioning, and Treatment Focus (Am Psychiatr Publ), 2022.PMID 37200888
  17. [17]Diedrich A, Voderholzer U Obsessive-compulsive personality disorder: a current review Curr Psychiatry Rep, 2015.PMID 25617042
  18. [18]Lugnegård T, Hallerbäck MU, Gillberg C Personality disorders and autism spectrum disorders: what are the connections? Compr Psychiatry, 2012.PMID 21821235
  19. [19]Gjerde LC, Czajkowski N, Røysamb E, Orstavik RE, et al. The heritability of avoidant and dependent personality disorder assessed by personal interview and questionnaire Acta Psychiatr Scand, 2012.PMID 22486635
  20. [20]Kim YR, Tyrer P, Mulder R, King JD, et al. ICD-11 classification of personality disorder: there is no other way forward Br J Psychiatry, 2026.PMID 41906979

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