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Psych TopicsEmergency psychiatry

Psych · Emergency psychiatry

Psychiatric emergencies

Also known as Acute agitation · Rapid tranquillisation · Severe behavioural disturbance · Excited delirium · Suicidal crisis · NMS · Serotonin syndrome · Catatonic emergency · Psychiatric emergency

Exam-exhaustive fellowship hub on psychiatric emergencies — agitation ladders with doses, suicidal crisis, medical mimics, SBD/ExDS frameworks, NMS and serotonin toxicity discriminators, lithium toxicity, catatonic emergency, capacity and least-restrictive involuntary care, ED-psych liaison and disposition. FRANZCP-primary, globally tagged.

high20 referencesUpdated 26 July 202611 min readVerification in progress

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Target exams

FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Fever, fluctuating attention, hypoxia, hypoglycaemia, or focal neurology with behavioural change — treat as medical emergency first, not primary psychiatric disease
  • Acute agitation with hyperthermia, extreme exertion, or collapse risk — manage as severe behavioural disturbance with medical resuscitation capacity
  • Lead-pipe rigidity, autonomic instability and fever after antipsychotics — stop dopamine antagonists and manage as NMS
  • Clonus, hyperreflexia and rapid onset after serotonergic drugs — stop serotonergics and manage as serotonin toxicity
  • IM olanzapine plus parenteral benzodiazepine — never co-administer; risk of profound respiratory depression
  • Catatonia with fever or autonomic instability — malignant catatonia pathway including ECT consideration
  • Active suicidal intent with accessible means — same-day senior review, means restriction, documented safety plan; do not discharge to an empty plan
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Study tools

Your progress

Saved on this device.

Target exams

FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Fever, fluctuating attention, hypoxia, hypoglycaemia, or focal neurology with behavioural change — treat as medical emergency first, not primary psychiatric disease
  • Acute agitation with hyperthermia, extreme exertion, or collapse risk — manage as severe behavioural disturbance with medical resuscitation capacity
  • Lead-pipe rigidity, autonomic instability and fever after antipsychotics — stop dopamine antagonists and manage as NMS
  • Clonus, hyperreflexia and rapid onset after serotonergic drugs — stop serotonergics and manage as serotonin toxicity
  • IM olanzapine plus parenteral benzodiazepine — never co-administer; risk of profound respiratory depression
  • Catatonia with fever or autonomic instability — malignant catatonia pathway including ECT consideration
  • Active suicidal intent with accessible means — same-day senior review, means restriction, documented safety plan; do not discharge to an empty plan
The one-line answer

A psychiatric emergency is any presentation in which mental disorder, substance intoxication or withdrawal, or a medical mimic creates imminent risk of death, serious harm, or irreversible deterioration. The fellowship sequence never changes: secure the scene and ABCDE first, exclude medical mimics, de-escalate before drugs, use oral then single-agent IM rapid tranquillisation with monitoring, never combine IM olanzapine with parenteral benzodiazepines, and match disposition to risk, capacity, and the least-restrictive legal path in your jurisdiction. This hub ties together the dedicated topics on acute agitation, suicide risk, catatonia, and the individual toxidromes.[1][14][15]

Meet the patient

A 24-year-old is brought to the ED by police at 2am. He is agitated, pacing, shouting that someone is trying to kill him. He has a laceration on his forehead. His observations are not yet recorded. The nursing staff ask you to sedate him so they can examine him.[1][14]

The registrar reaches for the IM olanzapine. The examiner's question stops the whole room: what did you check before you reached for the syringe? This topic is the answer to that question, and the answer is always the same sequence — safety, ABCDE, glucose, medical mimics, de-escalation, then pharmacology.[1][14]

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References20ShowHide
  1. [1]Patel MX, Sethi FN, Barnes TR, et al. Joint BAP NAPICU evidence-based consensus guidelines for the clinical management of acute disturbance: De-escalation and rapid tranquillisation J Psychopharmacol, 2018.PMID 29882463
  2. [2]Foo LK, Duffull SB, Calver L, et al. Population pharmacokinetics of intramuscular droperidol in acutely agitated patients Br J Clin Pharmacol, 2016.PMID 27530285
  3. [3]Huf G, Coutinho ES, Adams CE, et al. Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine BMJ, 2007.PMID 17954515
  4. [4]Dunkley EJ, Isbister GK, Sibbritt D, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity QJM, 2003.PMID 12925718
  5. [5]Boyer EW, Shannon M The serotonin syndrome N Engl J Med, 2005.PMID 15784664
  6. [6]Gurrera RJ, Caroff SN, Cohen A, et al. An international consensus study of neuroleptic malignant syndrome diagnostic criteria using the Delphi method J Clin Psychiatry, 2011.PMID 21733489
  7. [7]Gurrera RJ, Mortillaro G, Velamoor V, et al. A Validation Study of the International Consensus Diagnostic Criteria for Neuroleptic Malignant Syndrome J Clin Psychopharmacol, 2017.PMID 28027111
  8. [8]Bush G, Fink M, Petrides G, et al. Catatonia. I. Rating scale and standardized examination Acta Psychiatr Scand, 1996.PMID 8686483
  9. [9]Bush G, Fink M, Petrides G, et al. Catatonia. II. Treatment with lorazepam and electroconvulsive therapy Acta Psychiatr Scand, 1996.PMID 8686484
  10. [10]Fink M, Taylor MA The catatonia syndrome: forgotten but not gone Arch Gen Psychiatry, 2009.PMID 19884605
  11. [11]Vilke GM, Bozeman WP, Dawes DM, et al. Excited delirium syndrome (ExDS): treatment options and considerations J Forensic Leg Med, 2012.PMID 22390995
  12. [12]Walsh BM, Agboola IK, Coupet E Jr, et al. Revisiting Excited Delirium: Does the Diagnosis Reflect and Promote Racial Bias? West J Emerg Med, 2023.PMID 36976592
  13. [13]Isbister GK, Calver LA, Downes MA, et al. Ketamine as Rescue Treatment for Difficult-to-Sedate Severe Acute Behavioral Disturbance in the Emergency Department Ann Emerg Med, 2016.PMID 26899459
  14. [14]Anderson EL, Nordstrom K, Wilson MP, et al. American Association for Emergency Psychiatry Task Force on Medical Clearance of Adults Part I: Introduction, Review and Evidence-Based Guidelines West J Emerg Med, 2017.PMID 28210358
  15. [15]Wilson MP, Nordstrom K, Anderson EL, et al. American Association for Emergency Psychiatry Task Force on Medical Clearance of Adult Psychiatric Patients. Part II: Controversies over Medical Assessment, and Consensus Recommendations West J Emerg Med, 2017.PMID 28611885
  16. [16]Large M, Myles N, Myles H, et al. Suicide risk assessment among psychiatric inpatients: a systematic review and meta-analysis of high-risk categories Psychol Med, 2018.PMID 28874218
  17. [17]Large MM, Ryan CJ Suicide risk categorisation of psychiatric inpatients: what it might mean and why it is of no use Australas Psychiatry, 2014.PMID 24871970
  18. [18]Decker BS, Goldfarb DS, Dargan PI, et al. Extracorporeal Treatment for Lithium Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup Clin J Am Soc Nephrol, 2015.PMID 25583292
  19. [19]Spencer BWJ, Gergel T, Hotopf M, et al. Unwell in hospital but not incapable: cross-sectional study on the dissociation of decision-making capacity for treatment and research in in-patients with schizophrenia and related psychoses. Br J Psychiatry, 2018.PMID 29909778
  20. [20]Huf G, Coutinho ES, Adams CE, et al. Physical restraints versus seclusion room for management of people with acute aggression or agitation due to psychotic illness Psychol Med, 2012.PMID 22405443
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