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Psych TopicsEmergency psychiatry

Psych · Emergency psychiatry

Acute behavioural disturbance and excited delirium presentations

Also known as Acute behavioural disturbance · Acute behavioral disturbance · Severe behavioural disturbance · Excited delirium · Excited delirium syndrome · Hyperactive delirium with severe agitation · Agitated delirium · Extreme agitation emergency

Fellowship-depth topic on extreme acute behavioural disturbance (ABD) and contested excited-delirium (ExDS) presentations — ABD-first framing, medical resuscitation, hyperthermia and rhabdomyolysis risk, restraint hazards including positional asphyxia, ANZ ED droperidol and ketamine evidence, Project BETA and BAP principles, capacity and least-restrictive care, custody interface. FRANZCP-primary, globally tagged.

high18 referencesUpdated 26 July 202613 min readVerification in progress

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Target exams

FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Extreme continuous agitation with hyperthermia, collapse risk, or prolonged struggle — medical resuscitation emergency, not a forensic label
  • Prolonged prone restraint or chest compression — positional asphyxia and sudden death risk
  • Post-sedation unrousable patient or falling SpO2 — airway emergency, not 'settled'
  • Fever with fluctuating attention — delirium and medical work-up first
  • Using 'excited delirium' as sole diagnosis or cause of death without investigating trauma, restraint contribution, toxins, and natural disease
  • IM olanzapine plus parenteral benzodiazepine — profound respiratory depression risk
  • Deep polypharmacy sedation without monitoring or cooling plan for hyperthermia
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Your progress

Saved on this device.

Target exams

FRANZCPMRCPsychABPNMD-DNBNEET-SS

Red flags

  • Extreme continuous agitation with hyperthermia, collapse risk, or prolonged struggle — medical resuscitation emergency, not a forensic label
  • Prolonged prone restraint or chest compression — positional asphyxia and sudden death risk
  • Post-sedation unrousable patient or falling SpO2 — airway emergency, not 'settled'
  • Fever with fluctuating attention — delirium and medical work-up first
  • Using 'excited delirium' as sole diagnosis or cause of death without investigating trauma, restraint contribution, toxins, and natural disease
  • IM olanzapine plus parenteral benzodiazepine — profound respiratory depression risk
  • Deep polypharmacy sedation without monitoring or cooling plan for hyperthermia
The one-line fellowship answer

Prefer acute behavioural disturbance (ABD) language over the contested excited delirium label, and treat extreme continuous agitation as a medical resuscitation problem — ABCDE, glucose, temperature, cooling, safe positioning, and monitored parenteral sedation with named agents such as IM droperidol 5–10 mg and ketamine rescue under governance. Never use prolonged prone restraint. Investigate the cause, and document restraint physiology honestly.[1][2][7][16]

Extreme behavioural emergencies sit at the interface of emergency medicine, toxicology, psychiatry, and — too often — custody. This leaf goes deeper than the general agitation and rapid-tranquillisation ladder: it is about physiology that can kill, language that can mislead, and systems that must put medical care ahead of a forensic label.[2][3][11]

Meet the patient

A 32-year-old man is brought to the ED by police on a hot summer night. There was a prolonged foot pursuit; he fought four officers and is still struggling against the restraints. He is diaphoretic, incoherent, apparently indifferent to pain, and feels hot to touch. He has not been searched. Paramedics cannot get a set of observations. This is the classic stem — and the wrong word for it will fail the viva.[4][16]

Two questions dominate the next ten minutes, and the answers must come in the right order. Is this a medical emergency or a behavioural problem? — it is a medical emergency. What will you do in the next few minutes? — secure the airway-ready team, control behaviour quickly, never leave him prone, and start the physiological work-up. Everything below exists to make that sequence automatic.[2][13]

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References18ShowHide
  1. [1]Stolbach AI, Dargan PI, Greller HA, et al. ACMT Position Statement: End the Use of the Term "Excited Delirium" J Med Toxicol, 2023.PMID 37349654
  2. [2]McGuinness T, Lipsedge M 'Excited Delirium', acute behavioural disturbance, death and diagnosis Psychol Med, 2022.PMID 35546291
  3. [3]Gonin P, Beysard N, Yersin B, Carron PN Excited Delirium: A Systematic Review Acad Emerg Med, 2018.PMID 28990246
  4. [4]Takeuchi A, Ahern TL, Henderson SO Excited delirium West J Emerg Med, 2011.PMID 21691475
  5. [5]Vilke GM, DeBard ML, Chan TC, et al. Excited Delirium Syndrome (ExDS): defining based on a review of the literature J Emerg Med, 2012.PMID 21440403
  6. [6]Vilke GM, Bozeman WP, Dawes DM, et al. Excited delirium syndrome (ExDS): treatment options and considerations J Forensic Leg Med, 2012.PMID 22390995
  7. [7]Isbister GK, Calver LA, Page CB, et al. Randomized controlled trial of intramuscular droperidol versus midazolam for violence and acute behavioral disturbance: the DORM study Ann Emerg Med, 2010.PMID 20868907
  8. [8]Calver L, Page CB, Downes MA, et al. The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department Ann Emerg Med, 2015.PMID 25890395
  9. [9]Isbister GK, Calver LA, Downes MA, Page CB Ketamine as Rescue Treatment for Difficult-to-Sedate Severe Acute Behavioral Disturbance in the Emergency Department Ann Emerg Med, 2016.PMID 26899459
  10. [10]Isoardi KZ, Parker LE, Page CB, et al. Ketamine as a rescue treatment for severe acute behavioural disturbance: A prospective prehospital study Emerg Med Australas, 2021.PMID 33202484
  11. [11]Patel MX, Sethi FN, Barnes TR, et al. Joint BAP NAPICU evidence-based consensus guidelines for the clinical management of acute disturbance: De-escalation and rapid tranquillisation J Psychopharmacol, 2018.PMID 29882463
  12. [12]Richmond JS, Berlin JS, Fishkind AB, et al. Verbal De-escalation of the Agitated Patient: Consensus Statement of the American Association for Emergency Psychiatry Project BETA De-escalation Workgroup West J Emerg Med, 2012.PMID 22461917
  13. [13]Nordstrom K, Zun LS, Wilson MP, et al. Medical evaluation and triage of the agitated patient: consensus statement of the american association for emergency psychiatry project BETA medical evaluation workgroup West J Emerg Med, 2012.PMID 22461915
  14. [14]Wilson MP, Pepper D, Currier GW, et al. The psychopharmacology of agitation: consensus statement of the american association for emergency psychiatry project Beta psychopharmacology workgroup West J Emerg Med, 2012.PMID 22461918
  15. [15]Knox DK, Holloman GH Jr Use and avoidance of seclusion and restraint: consensus statement of the american association for emergency psychiatry project BETA seclusion and restraint workgroup West J Emerg Med, 2012.PMID 22461919
  16. [16]Weedn V, Steinberg A, Speth P Prone restraint cardiac arrest in in-custody and arrest-related deaths J Forensic Sci, 2022.PMID 35869602
  17. [17]Slocum S, Fiorillo M, Harding E, et al. In pursuit of inter-specialty consensus on excited delirium syndrome: a scoping literature review Forensic Sci Med Pathol, 2023.PMID 36350497
  18. [18]Spencer BWJ, Gergel T, Hotopf M, Owen GS Unwell in hospital but not incapable: cross-sectional study on the dissociation of decision-making capacity for treatment and research in in-patients with schizophrenia and related psychoses. Br J Psychiatry, 2018.PMID 29909778
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