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Psych MEQs / SAQsConsultation-liaison psychiatry

Psych MEQs / SAQs · Consultation-liaison psychiatry

Long COVID neuropsychiatry — assessment, pacing and the disability letter (MEQ)

FRANZCP-style modified essay on long COVID neuropsychiatry: WHO, NICE and RECOVER definitions, post-exertional malaise screening, defensible exclusion work-up, the graded-exercise controversy, symptom-titrated rehabilitation, treating comorbid mood and sleep disorder without implying aetiology, and the episodic-disability work letter.

20 marks20 min4 min readVerification in progress

Target exams

FRANZCPMRCPsychABPNMD-DNB
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Study tools

Target exams

FRANZCPMRCPsychABPNMD-DNB
Prompt
You are the consultation-liaison psychiatrist in a general hospital long COVID clinic. A 38-year-old intensive care nurse is referred fourteen months after a non-hospitalised SARS-CoV-2 infection. She reports profound fatigue, word-finding difficulty and losing the thread of conversations, unrefreshing sleep, and lightheadedness on standing. After a four-hundred-metre walk she is bed-bound for three days. Routine bloods taken by her general practitioner were normal. Two previous letters record a diagnosis of 'anxiety'. She has stopped clinical work, is on unpaid leave, and asks you to write to her employer. (i) State the definitions of long COVID you would use and outline the further history you require. (ii) Outline your differential and a defensible exclusion work-up, with a stopping point. (iii) The rehabilitation team proposes a twelve-week programme with fixed weekly increases in walking distance; state your response and justify it. (iv) Outline your management plan, including mood, anxiety and sleep. (v) State what her return-to-work letter must contain.
What the marker is looking for

The post-exertional malaise (PEM) probe asked explicitly, a named definition rather than a vague one, a bedside lying-to-standing measurement, an exclusion panel with a stated stopping point, refusal of fixed incremental exercise escalation with the NICE 2021 reasoning attached, full-strength treatment of mood and sleep without implying aetiology, and a work letter written in fluctuating-function language.[1][8][15][17][20]

(i) Definitions and further history — 5 marks

Name the definition you are using. WHO post-COVID-19 condition: usually 3 months from probable or confirmed infection, symptoms for at least 2 months, not explained by an alternative diagnosis, often fluctuating or relapsing. NICE separates ongoing symptomatic COVID-19 (4 to 12 weeks) from post-COVID-19 syndrome (beyond 12 weeks). RECOVER is a weighted research symptom index at six months or more, built for cohort consistency rather than clinic use.[1][2][3]

The history that changes management:[17][8][6]

  • PEM probe — "what happens the day after you overdo it?" Delayed, disproportionate, prolonged worsening is PEM and it decides the rehabilitation plan.[17][15]
  • Functional timeline — pre-morbid function, acute illness, nadir, best and worst day now; a seven-day activity diary.[1][17]
  • Orthostatic symptoms — standing, heat and post-prandial triggers; relief on lying down.[8]
  • Mood, anxiety, PTSD, alcohol, sleep and suicidality, screened openly with the reason stated aloud.[6][14]
  • Occupational and financial context, and whether she ever had a documented positive test.[20][1]
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References20ShowHide
  1. [1]Soriano JB, et al. A clinical case definition of post-COVID-19 condition by a Delphi consensus Lancet Infect Dis, 2022.PMID 34951953
  2. [2]Shah W, et al. Managing the long term effects of covid-19: summary of NICE, SIGN, and RCGP rapid guideline BMJ, 2021.PMID 33483331
  3. [3]Thaweethai T, et al. Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection JAMA, 2023.PMID 37278994
  4. [4]Davis HE, et al. Long COVID: major findings, mechanisms and recommendations Nat Rev Microbiol, 2023.PMID 36639608
  5. [5]Ceban F, et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis Brain Behav Immun, 2022.PMID 34973396
  6. [6]Taquet M, et al. Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients Lancet Psychiatry, 2022.PMID 35987197
  7. [7]Hampshire A, et al. Cognition and Memory after Covid-19 in a Large Community Sample N Engl J Med, 2024.PMID 38416429
  8. [8]Reis Carneiro D, et al. Clinical presentation and management strategies of cardiovascular autonomic dysfunction following a COVID-19 infection - A systematic review Eur J Neurol, 2023.PMID 36694382
  9. [9]Peluso MJ, Deeks SG Mechanisms of long COVID and the path toward therapeutics Cell, 2024.PMID 39326415
  10. [10]Swank Z, et al. Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae Clin Infect Dis, 2023.PMID 36052466
  11. [11]Pretorius E, et al. Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin Cardiovasc Diabetol, 2021.PMID 34425843
  12. [12]Fernández-Castañeda A, et al. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation Cell, 2022.PMID 35768006
  13. [13]Teodoro T, et al. A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review J Neurol Neurosurg Psychiatry, 2018.PMID 29735513
  14. [14]Sharpe M, Greco M Chronic fatigue syndrome and an illness-focused approach to care: controversy, morality and paradox Med Humanit, 2019.PMID 31213482
  15. [15]Kingdon C, et al. What Primary Care Practitioners Need to Know about the New NICE Guideline for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Adults Healthcare (Basel), 2022.PMID 36553962
  16. [16]White PD, et al. Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial Lancet, 2011.PMID 21334061
  17. [17]Pouliopoulou DV, et al. Prevalence and Impact of Postexertional Malaise on Recovery in Adults With Post-COVID-19 Condition: A Systematic Review With Meta-analysis Arch Phys Med Rehabil, 2025.PMID 39921187
  18. [18]Kuut TA, et al. Efficacy of Cognitive-Behavioral Therapy Targeting Severe Fatigue Following Coronavirus Disease 2019: Results of a Randomized Controlled Trial Clin Infect Dis, 2023.PMID 37155736
  19. [19]Wahlgren C, et al. Two-year follow-up of patients with post-COVID-19 condition in Sweden: a prospective cohort study Lancet Reg Health Eur, 2023.PMID 36855599
  20. [20]Stelson EA, et al. Return-to-work with long COVID: An Episodic Disability and Total Worker Health® analysis Soc Sci Med, 2023.PMID 37918226
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