Explaining esketamine for TRD and safety rules (CASC)

Station instructions (candidate)

You have 7 minutes. Explain why esketamine is being considered after multiple adequate antidepressant failures, how supervised clinic dosing works (not take-home), what happens in the observation period, common short-term effects (dissociation, nausea, blood-pressure rise), and how this differs from recreational ketamine harm. Compare with ECT using ELEKT-D-level honesty for nonpsychotic TRD without declaring ECT obsolete. Do not guarantee cure. Do not minimise addiction/diversion concerns — explain clinic controls.^{[1][2][3][4][5]}