Phys Vivas · infectious
Tuberculosis — Viva Defence
Structured DCE viva for tuberculosis: long-case defence of a migrant patient with smear-positive pulmonary TB and a new HIV diagnosis — regimen construction, ART timing, IRIS, contact tracing and adherence architecture.
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Opening statement (SASPOP, delivered aloud)
"Mr Alemu is a 34-year-old recent migrant with smear-positive, Xpert-confirmed pulmonary tuberculosis without molecular evidence of rifampicin resistance, complicated by a new diagnosis of HIV with a CD4 count of 120. His problems are: infectious pulmonary TB requiring urgent treatment and isolation; advanced HIV requiring antiretroviral therapy on a defined clock; the interaction and IRIS risks of treating both together; a household and workplace exposure that obliges contact tracing; and the social complexity of delivering six months of therapy to a night-shift worker in shared housing. My plan is to start standard four-drug therapy today with public-health notification, integrate ART within two weeks, build an adherence architecture around his life, and trace his contacts through the TB service." [1] [2]
References8ShowHide
- [1]Nahid P, Dorman SE, Alipanah N, et al. Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis Clin Infect Dis, 2016.PMID 27516382
- [2]Abdool Karim SS, Naidoo K, Grobler A, et al. Timing of initiation of antiretroviral drugs during tuberculosis therapy N Engl J Med, 2010.PMID 20181971
- [3]Blanc FX, Sok T, Laureillard D, et al. Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis N Engl J Med, 2011.PMID 22010913
- [4]Meintjes G, Wilkinson RJ, Morroni C, et al. Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome AIDS, 2010.PMID 20808204
- [5]Török ME, Yen NT, Chau TT, et al. Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)--associated tuberculous meningitis Clin Infect Dis, 2011.PMID 21596680
- [6]Getahun H, Matteelli A, Chaisson RE, Raviglione M. Latent Mycobacterium tuberculosis infection N Engl J Med, 2015.PMID 26017823
- [7]Lewinsohn DM, Leonard MK, LoBue PA, et al. Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children Clin Infect Dis, 2017.PMID 28052967
- [8]Menzies D, Adjobimey M, Ruslami R, et al. Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults N Engl J Med, 2018.PMID 30067931