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Phys Topicsgeneral-medicine

Phys · general-medicine

Perioperative Medicine — Physician Assessment and Optimisation Before Surgery

Also known as perioperative medicine · preoperative assessment · preoperative cardiac risk · Revised Cardiac Risk Index · Lee index · RCRI · metabolic equivalents · MET capacity · preoperative functional capacity · perioperative diabetes · variable rate intravenous insulin infusion · VRIII · GKI · warfarin bridging · DOAC perioperative management · VTE prophylaxis · Caprini score · Padua score · enhanced recovery after surgery · ERAS · prothrombin complex concentrate · PCC · idarucizumab · andexanet alfa

Consultant-physician-depth guide to perioperative medicine: preoperative cardiac risk stratification (Revised Cardiac Risk Index, MET capacity, stress testing), pulmonary optimisation, perioperative diabetes management (metformin, SGLT2 inhibitors, insulin, variable-rate IV insulin infusion), anticoagulation management and reversal (warfarin bridging, DOACs, PCC, idarucizumab, andexanet alfa), chronic medication management, VTE prophylaxis (Caprini, Padua), postoperative complications, and Enhanced Recovery After Surgery (ERAS). Structured for FRACP DWE and DCE preparation.

high11 referencesUpdated 26 July 202615 min readVerification in progress

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FRACP DWEFRACP DCEMRCP Part 1MRCP Part 2MRCP PACESABIM Internal Medicine

Red flags

  • Initiating a beta-blocker on the morning of surgery in a beta-blocker-naive patient — POISE showed increased stroke and mortality from perioperative hypotension and bradycardia; continue existing beta-blockers but do not start them acutely pre-op
  • Stopping aspirin in a patient with a recent coronary stent — stent thrombosis and fatal MI; continue aspirin through surgery unless bleeding risk is extreme, and never stop dual antiplatelet therapy within the minimum stent period
  • Continuing an SGLT2 inhibitor into surgery — euglycaemic diabetic ketoacidosis under fasting and surgical stress; stop SGLT2 inhibitors 3 days before elective surgery
  • Using a sliding-scale insulin regimen perioperatively — obsolete and associated with poor glycaemic control and hyperglycaemia; use a variable-rate intravenous insulin infusion (VRIII) with glucose–potassium–insulin monitoring when insulin is required
  • Failing to bridge high-thrombotic-risk warfarin patients (mechanical valve, recent VTE, AF with rheumatic disease) — catastrophic thrombosis; bridge with LMWH when the annual thrombotic risk is high
  • Withholding VTE prophylaxis in a high-Caprini surgical patient — DVT and fatal PE; the commonest preventable cause of perioperative death is venous thromboembolism
  • Reversing warfarin with vitamin K alone for major bleeding — too slow; give 4-factor PCC plus intravenous vitamin K for life-threatening bleeding, because PCC reverses within minutes while vitamin K takes 6 to 12 hours to work
  • Pursuing coronary revascularisation purely to 'clear for surgery' in an asymptomatic patient — the CARP trial showed no benefit; revascularise only for cardiac indications that would mandate it independent of surgery
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FRACP DWEFRACP DCEMRCP Part 1MRCP Part 2MRCP PACESABIM Internal Medicine

Red flags

  • Initiating a beta-blocker on the morning of surgery in a beta-blocker-naive patient — POISE showed increased stroke and mortality from perioperative hypotension and bradycardia; continue existing beta-blockers but do not start them acutely pre-op
  • Stopping aspirin in a patient with a recent coronary stent — stent thrombosis and fatal MI; continue aspirin through surgery unless bleeding risk is extreme, and never stop dual antiplatelet therapy within the minimum stent period
  • Continuing an SGLT2 inhibitor into surgery — euglycaemic diabetic ketoacidosis under fasting and surgical stress; stop SGLT2 inhibitors 3 days before elective surgery
  • Using a sliding-scale insulin regimen perioperatively — obsolete and associated with poor glycaemic control and hyperglycaemia; use a variable-rate intravenous insulin infusion (VRIII) with glucose–potassium–insulin monitoring when insulin is required
  • Failing to bridge high-thrombotic-risk warfarin patients (mechanical valve, recent VTE, AF with rheumatic disease) — catastrophic thrombosis; bridge with LMWH when the annual thrombotic risk is high
  • Withholding VTE prophylaxis in a high-Caprini surgical patient — DVT and fatal PE; the commonest preventable cause of perioperative death is venous thromboembolism
  • Reversing warfarin with vitamin K alone for major bleeding — too slow; give 4-factor PCC plus intravenous vitamin K for life-threatening bleeding, because PCC reverses within minutes while vitamin K takes 6 to 12 hours to work
  • Pursuing coronary revascularisation purely to 'clear for surgery' in an asymptomatic patient — the CARP trial showed no benefit; revascularise only for cardiac indications that would mandate it independent of surgery
The one-line answer

Perioperative medicine is the physician's job of making a complex patient safe for surgery without over-investigating them. Five questions decide everything: what is the cardiac risk? (Revised Cardiac Risk Index plus functional capacity — stress testing only if the result will change management), is the lung ready? (stop smoking, optimise COPD), how is the diabetes managed? (stop SGLT2 inhibitors three days before, use a variable-rate intravenous insulin infusion, never a sliding scale), what happens to the anticoagulant? (stop, bridge or continue by thrombotic versus bleeding risk), and what is the VTE risk? (Caprini for surgical, Padua for medical). The recurring trap: treatments that seem protective — starting a beta-blocker, giving aspirin, revascularising a coronary — are harmful or useless when applied routinely.[1]

Meet the patient

Mr Rossi, seventy-four, is in the preadmission clinic before an open hemicolectomy for cancer. He has atrial fibrillation on warfarin (a mechanical mitral valve), type 2 diabetes on insulin and dapagliflozin, COPD on dual inhaled therapy, and takes ramipril, bisoprolol and atorvastatin. He still smokes ten a day. His HbA1c is 64 mmol per mol. The question on every perioperative long case is the same: how do I get this man through surgery without a cardiac event, a thrombosis, a bleed, or an euglycaemic ketoacidosis?[1]

This is the multi-morbidity archetype. Perioperative medicine rewards restraint, risk stratification, and continuation of the drugs that are working. The treatments that seem protective — starting a beta-blocker on the morning of surgery, giving aspirin to "clear" the patient, revascularising a stable coronary — are the ones that harm. The physician who can name the five questions, score the risk, and write a dated medication plan is the one who keeps the patient safe.[1]

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References11ShowHide
  1. [1]Lee TH, Marcantonio ER, Mangione CM, et al. Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery Circulation, 1999.PMID 10477528
  2. [2]Devereaux PJ, Yang H, Yusuf S, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial Lancet, 2008.PMID 18479744
  3. [3]Devereaux PJ, Mrkobrada M, Sessler DI, et al. Aspirin in patients undergoing noncardiac surgery N Engl J Med, 2014.PMID 24679062
  4. [4]McFalls EO, Ward HB, Moritz TE, et al. Coronary-artery revascularization before elective major vascular surgery N Engl J Med, 2004.PMID 15625331
  5. [5]Ljungqvist O, Scott M, Fearon KC Enhanced Recovery After Surgery: A Review JAMA Surg, 2017.PMID 28097305
  6. [6]Barbar S, Noventa F, Rossetto V, et al. A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score J Thromb Haemost, 2010.PMID 20738765
  7. [7]Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest, 2012.PMID 22315263
  8. [8]Pollack CV Jr, Reilly PA, Eikelboom J, et al. Idarucizumab for Dabigatran Reversal N Engl J Med, 2015.PMID 26095746
  9. [9]Connolly SJ, Milling TJ Jr, Eikelboom JW, et al. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors N Engl J Med, 2016.PMID 27573206
  10. [10]Sarode R, Milling TJ Jr, Refaai MA, et al. Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study Circulation, 2013.PMID 23935011
  11. [11]Sanders RD, Nicholson A, Lewis SR, Smith AF, Alderson P Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery Cochrane Database Syst Rev, 2013.PMID 23824754

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