Phys · general-medicine

Drug Allergy and Desensitisation

Also known as drug hypersensitivity · drug allergy · penicillin allergy · beta-lactam allergy · drug desensitisation · rapid drug desensitisation · drug provocation testing · aspirin-exacerbated respiratory disease · AERD · Samter triad · DRESS · drug reaction with eosinophilia and systemic symptoms · Stevens-Johnson syndrome · SJS · toxic epidermal necrolysis · TEN · SCORTEN

Consultant-physician-depth guide to drug allergy and desensitisation for FRACP DWE and DCE — the allergy-versus-intolerance distinction, the immediate IgE-mediated versus delayed T-cell mediated classification, beta-lactam allergy with penicillin skin testing and side-chain-based cross-reactivity and the modern delabeling strategy, non-beta-lactam allergies (sulfonamide, NSAID hypersensitivity and aspirin-exacerbated respiratory disease, local anaesthetics, radiocontrast media), the severe cutaneous adverse reactions DRESS and Stevens-Johnson syndrome or toxic epidermal necrolysis with the RegiSCAR and SCORTEN scores, and the principle and indications of drug desensitisation with the Brigham 12-step protocol and drug provocation testing as the diagnostic gold standard.