Phys Written Answers · haematological
Myeloproliferative Neoplasms — Written Clinical Reasoning
DCE-style written reasoning for Myeloproliferative Neoplasms.
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Target exams
SAQ 1 — Integrated plan (12 marks)
Prompt: Provide a prioritised problem list and management sequence for this presentation. [1] [2]
Model Answer
1. Frame and red flags (3 marks) [1]
State the working diagnosis/syndrome, acuity, and what would force emergency treatment now. [1] [2]
2. Discriminating assessment (3 marks) [2]
List the key history, examination and investigations that separate dangerous differentials from benign mimics. [1] [2]
3. Treatment sequence (4 marks) [1] [3]
Immediate stabilisation, disease-specific therapy, monitoring, and complications prevention. [1] [2] [3]
4. Follow-up and communication (2 marks) [2]
Disposition, safety-net advice, and who owns follow-up. [1] [2]
References3ShowHide
- [1]Tefferi A Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management American journal of hematology, 2023.PMID 36680511
- [2]Tremblay D, Kremyanskaya M, Mascarenhas J et al. Diagnosis and Treatment of Polycythemia Vera: A Review JAMA, 2025.PMID 39556352
- [3]Tefferi A, Gangat N, Loscocco GG et al. Essential Thrombocythemia: A Review JAMA, 2025.PMID 39869325