Phys Written Answers · rheumatological
Immunological Investigation Immunoglobulins Complement Flow Cytometry — Written Clinical Reasoning
DCE-style written reasoning for Immunological Investigation Immunoglobulins Complement Flow Cytometry.
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SAQ 1 — Integrated plan (12 marks)
Prompt: Provide a prioritised problem list and management sequence for this presentation. [5]
Model Answer
1. Frame and red flags (3 marks) [6]
State the working diagnosis/syndrome, acuity, and what would force emergency treatment now. [7]
2. Discriminating assessment (3 marks) [8]
List the key history, examination and investigations that separate dangerous differentials from benign mimics. [1]
3. Treatment sequence (4 marks) [5]
Immediate stabilisation, disease-specific therapy, monitoring, and complications prevention. [6]
4. Follow-up and communication (2 marks) [7]
Disposition, safety-net advice, and who owns follow-up. [8]
References5ShowHide
- [1]Seitz M, Villiger P [Value of laboratory diagnosis in inflammatory rheumatologic diseases] Praxis (Bern 1994), 2002.PMID 11845615
- [5]Ye S, Li D, Liu F, Lei M, et al. In vitro evaluation of the biological activities of IgG in seven Chinese intravenous immunoglobulin preparations J Pharm Biomed Anal, 2018.PMID 29413980
- [6]Barth MJ, Mavis C, Czuczman MS, Hernandez-Ilizaliturri FJ Ofatumumab Exhibits Enhanced In Vitro and In Vivo Activity Compared to Rituximab in Preclinical Models of Mantle Cell Lymphoma Clin Cancer Res, 2015.PMID 25964296
- [7]Barsalou J, Saint-Cyr C, Drouin E, Le Deist F, et al. High prevalence of primary immune deficiencies in children with autoimmune disorders Clin Exp Rheumatol, 2011.PMID 21345299
- [8]Dialynas DP, Wilde DB, Marrack P, Pierres A, et al. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity Immunol Rev, 1983.PMID 6195085