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Phys Written Answersrheumatological

Phys Written Answers · rheumatological

Complement Deficiencies AND Recurrent Infections — Written Clinical Reasoning

DCE-style written reasoning for Complement Deficiencies AND Recurrent Infections.

1 min readVerification in progress

Target exams

FRACP DCEMRCP Part 2
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Study tools

Target exams

FRACP DCEMRCP Part 2
Prompt
DCE-style written reasoning for Complement Deficiencies AND Recurrent Infections.

SAQ 1 — Integrated plan (12 marks)

Prompt: Provide a prioritised problem list and management sequence for this presentation. [1] [2]

Model Answer

1. Frame and red flags (3 marks) [1]

State the working diagnosis/syndrome, acuity, and what would force emergency treatment now. [1] [2]

2. Discriminating assessment (3 marks) [2]

List the key history, examination and investigations that separate dangerous differentials from benign mimics. [1] [2]

3. Treatment sequence (4 marks) [1] [3]

Immediate stabilisation, disease-specific therapy, monitoring, and complications prevention. [1] [2] [3]

4. Follow-up and communication (2 marks) [2]

Disposition, safety-net advice, and who owns follow-up. [1] [2]

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References5ShowHide
  1. [1]Mottaghipisheh H, Jahromi AM, Mirzaei F, Meri S, et al. Homozygous C1qA Deficiency Presenting as Early-Onset Systemic Lupus Erythematosus: A Case Report With a Literature Review Case Reports Immunol, 2026.PMID 42147803
  2. [2]Consolini R, Maestrini G, Abu-Rumeileh S, Costagliola G The Intertwining Between Arthritis and Inborn Errors of Immunity J Clin Med, 2026.PMID 42123030
  3. [3]Boccon-Gibod I, Fain O, Gobert D, Debord S, et al. French protocol for the diagnosis and management of hereditary angioedema Rev Med Interne, 2025.PMID 41168057
  4. [4]Schejbel L, Fadnes D, Permin H, Lappegård KT, et al. Primary complement C5 deficiencies - molecular characterization and clinical review of two families Immunobiology, 2013.PMID 23743184
  5. [8]Donadoni M, La Cava L, Bizzi E, Popescu Janu V, et al. Hereditary Angioedema Prophylaxis Therapy: Berotralstat and Lanadelumab Safety Profile Medicina (Kaunas), 2025.PMID 41303734
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